Inhibition of CXCR3‐mediated chemotaxis by the human chemokine receptor‐like protein CCX‐CKR

Background and Purpose Induction of cellular migration is the primary effect of chemokine receptor activation. However, several chemokine receptor‐like proteins bind chemokines without subsequent induction of intracellular signalling and chemotaxis. It has been suggested that they act as chemokine s...

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Veröffentlicht in:	British journal of pharmacology 2013-03, Vol.168 (6), p.1375-1387
Hauptverfasser:	Vinet, J, Zwam, M, Dijkstra, IM, Brouwer, N, Weering, HRJ, Watts, A, Meijer, M, Fokkens, MR, Kannan, V, Verzijl, D, Vischer, HF, Smit, MJ, Leurs, R, Biber, K, Boddeke, HWGM
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell adhesion & migration Cells, Cultured chemokine receptors Chemokines Chemokines - metabolism Chemotaxis, Leukocyte Down-Regulation Fluorescence Resonance Energy Transfer Gene Expression Regulation HEK293 Cells heteromerization Humans Immunohistochemistry Kinetics Ligands Luminescent Proteins - genetics Luminescent Proteins - metabolism Protein Multimerization Protein Transport Receptors, CCR - genetics Receptors, CCR - metabolism Receptors, CXCR3 - genetics Receptors, CXCR3 - metabolism Recombinant Fusion Proteins - metabolism Recombinant Proteins - metabolism Research Papers RNA, Messenger T cells T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism
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