Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells

The anti-angiogenic activity of chemotherapy is both dose- and schedule-dependent. While conventional maximum tolerated dose (MTD) chemotherapy exerts only mild and reversible anti-angiogenic effects, low-dose metronomic (LDM) chemotherapy was developed to specifically target tumour angiogenesis. Ho...

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Veröffentlicht in:	Angiogenesis (London) 2013-04, Vol.16 (2), p.373-386
Hauptverfasser:	Pasquier, Eddy, Tuset, Maria-Pia, Street, Janine, Sinnappan, Snega, MacKenzie, Karen L., Braguer, Diane, Andre, Nicolas, Kavallaris, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Base Sequence Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Cardiology Cell Biology Cell Line, Transformed DNA Primers Dose-Response Relationship, Drug Drug Administration Schedule Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Gene Silencing Humans Neovascularization, Pathologic - prevention & control Oncology Ophthalmology Original Paper Polymerase Chain Reaction RNA, Small Interfering Tubulin - metabolism
Online-Zugang:	Volltext
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