1,25-Dihydroxyvitamin D3 Regulation of Fibroblast Growth Factor-23 Expression in Bone Cells: Evidence for Primary and Secondary Mechanisms Modulated by Leptin and Interleukin-6

Fibroblast growth factor-23 (FGF23) is a circulating hormone that acts to correct hyperphosphatemic states by inhibiting renal phosphate reabsorption and to prevent hypervitaminosis D by feedback repressing 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) biosynthesis. FGF23 gene expression in the osteob...

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Veröffentlicht in:	Calcified tissue international 2013-04, Vol.92 (4), p.339-353
Hauptverfasser:	Saini, Rimpi K., Kaneko, Ichiro, Jurutka, Peter W., Forster, Ryan, Hsieh, Antony, Hsieh, Jui-Cheng, Haussler, Mark R., Whitfield, G. Kerr
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Cell Biology Endocrinology Life Sciences Original Research Orthopedics
Online-Zugang:	Volltext
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