β-Adrenergic Regulation of Cardiac Progenitor Cell Death Versus Survival and Proliferation

RATIONALE:Short-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death. Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation research 2013-02, Vol.112 (3), p.476-486
Hauptverfasser:	Khan, Mohsin, Mohsin, Sadia, Avitabile, Daniele, Siddiqi, Sailay, Nguyen, Jonathan, Wallach, Kathleen, Quijada, Pearl, McGregor, Michael, Gude, Natalie, Alvarez, Roberto, Tilley, Douglas G, Koch, Walter J, Sussman, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-2 Receptor Agonists - pharmacology Adrenergic beta-2 Receptor Antagonists - pharmacology Animals Cell Death Cell Proliferation - drug effects Cell Survival Cells, Cultured Coculture Techniques Cyclin D1 - metabolism Disease Models, Animal Dose-Response Relationship, Drug G-Protein-Coupled Receptor Kinase 2 - metabolism Humans Male Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - surgery Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Myocytes, Cardiac - transplantation Nitric Oxide Synthase Type III - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-kit - metabolism Receptors, Adrenergic, beta-1 - drug effects Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-1 - metabolism Receptors, Adrenergic, beta-2 - drug effects Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism RNA Interference Signal Transduction - drug effects Stem Cell Transplantation Stem Cells - drug effects Stem Cells - metabolism Stem Cells - pathology Time Factors Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!