Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity
Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functio...
Gespeichert in:
| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2013-02, Vol.66, p.151-160 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 160 |
|---|---|
| container_issue | |
| container_start_page | 151 |
| container_title | NeuroImage (Orlando, Fla.) |
| container_volume | 66 |
| creator | Fox, Michael D. Liu, Hesheng Pascual-Leone, Alvaro |
| description | Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functional connectivity with remote regions including the subgenual cingulate and suggested that functional connectivity with these remote regions might be used to identify optimized left DLPFC targets for TMS. However it remains unclear if and how this connectivity-based targeting approach should be applied at the single-subject level to potentially individualize therapy to specific patients. In this article we show that individual differences in DLPFC connectivity are large, reproducible across sessions, and can be used to generate individualized DLPFC TMS targets that may prove clinically superior to those selected on the basis of group-average connectivity. Factors likely to improve individualized targeting including the use of seed maps and the focality of stimulation are investigated and discussed. The techniques presented here may be applicable to individualized targeting of focal brain stimulation across a range of diseases and stimulation modalities and can be experimentally tested in clinical trials.
► There is significant individual variability in the connectivity of the left DLPFC. ► Individual differences in DLPFC connectivity are reproducible across days. ► Individualized TMS targets appear superior to population-based targets. ► Seed maps improve signal/noise compared to small seed regions. ► Individualized targeting is likely of greater benefit with more focal stimulation. |
| doi_str_mv | 10.1016/j.neuroimage.2012.10.082 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3594474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053811912010865</els_id><sourcerecordid>3396571511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-79c25ec82f122d71bb9f680b609fa86b33cd38c449c366b7ff641359a1815b53</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEoh_wF1AkhMRlF48Tx84FiVYUKhVxYO-W44-tV1l7sZ1F7a9nol1a4NKTLc_zvhrPvFVVA1kCge7DZhnslKLfqrVdUgIUn5dE0GfVKZCeLXrG6fP5zpqFAOhPqrOcN4SQHlrxsjqhDbSUdPy0ur82NhTvvFbFx1BHVye7S9FM2g-jrX0wfu_NpEZ_b01dVFrbkmsXU12SVWWL6llkUGRzni1--XJbr779qAeVUYIvPpTkQ_a61jEEqwtalrtX1QunxmxfH8_zanX1eXX5dXHz_cv15aebhWaclAXvNWVWC-qAUsNhGHrXCTJ0pHdKdEPTaNMI3ba9brpu4M51LTSsVyCADaw5rz4ebHfTsLVGY8NJjXKXcHrpTkbl5b-V4G_lOu4lerQtb9Hg_dEgxZ-TzUVufdZ2HFWwccoSOmj6ljeMPI0yQjg2D7Pr2__QTZxSwEEgxSihlBNAShwonWLOybqHvoHIOQpyIx-jIOcozBWMAkrf_P3vB-Gf3SPw7giorNXokgra50eOA2YJBHIXB87ikvbeJpm1t0Fb4xPuUpron-7mN82c2bo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552022701</pqid></control><display><type>article</type><title>Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>ProQuest Central UK/Ireland</source><creator>Fox, Michael D. ; Liu, Hesheng ; Pascual-Leone, Alvaro</creator><creatorcontrib>Fox, Michael D. ; Liu, Hesheng ; Pascual-Leone, Alvaro</creatorcontrib><description>Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functional connectivity with remote regions including the subgenual cingulate and suggested that functional connectivity with these remote regions might be used to identify optimized left DLPFC targets for TMS. However it remains unclear if and how this connectivity-based targeting approach should be applied at the single-subject level to potentially individualize therapy to specific patients. In this article we show that individual differences in DLPFC connectivity are large, reproducible across sessions, and can be used to generate individualized DLPFC TMS targets that may prove clinically superior to those selected on the basis of group-average connectivity. Factors likely to improve individualized targeting including the use of seed maps and the focality of stimulation are investigated and discussed. The techniques presented here may be applicable to individualized targeting of focal brain stimulation across a range of diseases and stimulation modalities and can be experimentally tested in clinical trials.
► There is significant individual variability in the connectivity of the left DLPFC. ► Individual differences in DLPFC connectivity are reproducible across days. ► Individualized TMS targets appear superior to population-based targets. ► Seed maps improve signal/noise compared to small seed regions. ► Individualized targeting is likely of greater benefit with more focal stimulation.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2012.10.082</identifier><identifier>PMID: 23142067</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Antidepressants ; Biological and medical sciences ; Brain ; Brain Mapping ; Clinical trials ; Depression ; Depression - therapy ; Dorsolateral prefrontal cortex ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Image Interpretation, Computer-Assisted - methods ; Individual differences ; Intrinsic connectivity ; Inventors ; Male ; Middle Aged ; MRI ; NMR ; Noise ; Nuclear magnetic resonance ; Patients ; Precision Medicine ; Prefrontal Cortex - physiology ; Resting state functional connectivity ; Seed map ; Studies ; Subgenual ; TMS ; Transcranial magnetic stimulation ; Transcranial Magnetic Stimulation - methods ; Variability ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2013-02, Vol.66, p.151-160</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 1, 2013</rights><rights>2012 Elsevier Inc. All rights reserved 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-79c25ec82f122d71bb9f680b609fa86b33cd38c449c366b7ff641359a1815b53</citedby><cites>FETCH-LOGICAL-c570t-79c25ec82f122d71bb9f680b609fa86b33cd38c449c366b7ff641359a1815b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1552022701?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27110918$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23142067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fox, Michael D.</creatorcontrib><creatorcontrib>Liu, Hesheng</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><title>Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functional connectivity with remote regions including the subgenual cingulate and suggested that functional connectivity with these remote regions might be used to identify optimized left DLPFC targets for TMS. However it remains unclear if and how this connectivity-based targeting approach should be applied at the single-subject level to potentially individualize therapy to specific patients. In this article we show that individual differences in DLPFC connectivity are large, reproducible across sessions, and can be used to generate individualized DLPFC TMS targets that may prove clinically superior to those selected on the basis of group-average connectivity. Factors likely to improve individualized targeting including the use of seed maps and the focality of stimulation are investigated and discussed. The techniques presented here may be applicable to individualized targeting of focal brain stimulation across a range of diseases and stimulation modalities and can be experimentally tested in clinical trials.
► There is significant individual variability in the connectivity of the left DLPFC. ► Individual differences in DLPFC connectivity are reproducible across days. ► Individualized TMS targets appear superior to population-based targets. ► Seed maps improve signal/noise compared to small seed regions. ► Individualized targeting is likely of greater benefit with more focal stimulation.</description><subject>Adult</subject><subject>Antidepressants</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain Mapping</subject><subject>Clinical trials</subject><subject>Depression</subject><subject>Depression - therapy</subject><subject>Dorsolateral prefrontal cortex</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Individual differences</subject><subject>Intrinsic connectivity</subject><subject>Inventors</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>NMR</subject><subject>Noise</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Precision Medicine</subject><subject>Prefrontal Cortex - physiology</subject><subject>Resting state functional connectivity</subject><subject>Seed map</subject><subject>Studies</subject><subject>Subgenual</subject><subject>TMS</subject><subject>Transcranial magnetic stimulation</subject><subject>Transcranial Magnetic Stimulation - methods</subject><subject>Variability</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk1v1DAQhiMEoh_wF1AkhMRlF48Tx84FiVYUKhVxYO-W44-tV1l7sZ1F7a9nol1a4NKTLc_zvhrPvFVVA1kCge7DZhnslKLfqrVdUgIUn5dE0GfVKZCeLXrG6fP5zpqFAOhPqrOcN4SQHlrxsjqhDbSUdPy0ur82NhTvvFbFx1BHVye7S9FM2g-jrX0wfu_NpEZ_b01dVFrbkmsXU12SVWWL6llkUGRzni1--XJbr779qAeVUYIvPpTkQ_a61jEEqwtalrtX1QunxmxfH8_zanX1eXX5dXHz_cv15aebhWaclAXvNWVWC-qAUsNhGHrXCTJ0pHdKdEPTaNMI3ba9brpu4M51LTSsVyCADaw5rz4ebHfTsLVGY8NJjXKXcHrpTkbl5b-V4G_lOu4lerQtb9Hg_dEgxZ-TzUVufdZ2HFWwccoSOmj6ljeMPI0yQjg2D7Pr2__QTZxSwEEgxSihlBNAShwonWLOybqHvoHIOQpyIx-jIOcozBWMAkrf_P3vB-Gf3SPw7giorNXokgra50eOA2YJBHIXB87ikvbeJpm1t0Fb4xPuUpron-7mN82c2bo</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Fox, Michael D.</creator><creator>Liu, Hesheng</creator><creator>Pascual-Leone, Alvaro</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7QO</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity</title><author>Fox, Michael D. ; Liu, Hesheng ; Pascual-Leone, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-79c25ec82f122d71bb9f680b609fa86b33cd38c449c366b7ff641359a1815b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Antidepressants</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain Mapping</topic><topic>Clinical trials</topic><topic>Depression</topic><topic>Depression - therapy</topic><topic>Dorsolateral prefrontal cortex</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Individual differences</topic><topic>Intrinsic connectivity</topic><topic>Inventors</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>NMR</topic><topic>Noise</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Precision Medicine</topic><topic>Prefrontal Cortex - physiology</topic><topic>Resting state functional connectivity</topic><topic>Seed map</topic><topic>Studies</topic><topic>Subgenual</topic><topic>TMS</topic><topic>Transcranial magnetic stimulation</topic><topic>Transcranial Magnetic Stimulation - methods</topic><topic>Variability</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fox, Michael D.</creatorcontrib><creatorcontrib>Liu, Hesheng</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fox, Michael D.</au><au>Liu, Hesheng</au><au>Pascual-Leone, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>66</volume><spage>151</spage><epage>160</epage><pages>151-160</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Transcranial magnetic stimulation (TMS) to the left dorsolateral prefrontal cortex (DLPFC) is used clinically for the treatment of depression however outcomes vary greatly between patients. We have shown that average clinical efficacy of different left DLPFC TMS sites is related to intrinsic functional connectivity with remote regions including the subgenual cingulate and suggested that functional connectivity with these remote regions might be used to identify optimized left DLPFC targets for TMS. However it remains unclear if and how this connectivity-based targeting approach should be applied at the single-subject level to potentially individualize therapy to specific patients. In this article we show that individual differences in DLPFC connectivity are large, reproducible across sessions, and can be used to generate individualized DLPFC TMS targets that may prove clinically superior to those selected on the basis of group-average connectivity. Factors likely to improve individualized targeting including the use of seed maps and the focality of stimulation are investigated and discussed. The techniques presented here may be applicable to individualized targeting of focal brain stimulation across a range of diseases and stimulation modalities and can be experimentally tested in clinical trials.
► There is significant individual variability in the connectivity of the left DLPFC. ► Individual differences in DLPFC connectivity are reproducible across days. ► Individualized TMS targets appear superior to population-based targets. ► Seed maps improve signal/noise compared to small seed regions. ► Individualized targeting is likely of greater benefit with more focal stimulation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>23142067</pmid><doi>10.1016/j.neuroimage.2012.10.082</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-8119 |
| ispartof | NeuroImage (Orlando, Fla.), 2013-02, Vol.66, p.151-160 |
| issn | 1053-8119 1095-9572 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3594474 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; ProQuest Central UK/Ireland |
| subjects | Adult Antidepressants Biological and medical sciences Brain Brain Mapping Clinical trials Depression Depression - therapy Dorsolateral prefrontal cortex Female Fundamental and applied biological sciences. Psychology Humans Image Interpretation, Computer-Assisted - methods Individual differences Intrinsic connectivity Inventors Male Middle Aged MRI NMR Noise Nuclear magnetic resonance Patients Precision Medicine Prefrontal Cortex - physiology Resting state functional connectivity Seed map Studies Subgenual TMS Transcranial magnetic stimulation Transcranial Magnetic Stimulation - methods Variability Vertebrates: nervous system and sense organs Young Adult |
| title | Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T12%3A40%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Identification%20of%20reproducible%20individualized%20targets%20for%20treatment%20of%20depression%20with%20TMS%20based%20on%20intrinsic%20connectivity&rft.jtitle=NeuroImage%20(Orlando,%20Fla.)&rft.au=Fox,%20Michael%20D.&rft.date=2013-02-01&rft.volume=66&rft.spage=151&rft.epage=160&rft.pages=151-160&rft.issn=1053-8119&rft.eissn=1095-9572&rft_id=info:doi/10.1016/j.neuroimage.2012.10.082&rft_dat=%3Cproquest_pubme%3E3396571511%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1552022701&rft_id=info:pmid/23142067&rft_els_id=S1053811912010865&rfr_iscdi=true |