Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics

Glioblastoma multiforme (GBM) is one of the most aggressive human malignancies with a poor patient prognosis. Ionizing radiation either alone or adjuvant after surgery is part of standard treatment for GBM but remains primarily noncurative. The mechanisms underlying tumor radioresistance are manifol...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2013-03, Vol.73 (5), p.1481-1490
Hauptverfasser:	XUEFENG GAO, MCDONALD, J. Tyson, HLATKY, Lynn, ENDERLING, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cell Division - radiation effects Cell Line, Tumor Dose Fractionation Glioma - pathology Glioma - radiotherapy Humans Medical sciences Models, Biological Neoplastic Stem Cells - radiation effects Neurology Pharmacology. Drug treatments Tumors Tumors of the nervous system. Phacomatoses
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