Abuse liability and reinforcing efficacy of oral tramadol in humans

Abstract Background Tramadol, a monoaminergic reuptake inhibitor, is hepatically metabolized to an opioid agonist (M1). This atypical analgesic is generally considered to have limited abuse liability. Recent reports of its abuse have increased in the U.S., leading to more stringent regulation in som...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug and alcohol dependence 2013-04, Vol.129 (1), p.116-124
Hauptverfasser:	Babalonis, Shanna, Lofwall, Michelle R, Nuzzo, Paul A, Siegel, Anthony J, Walsh, Sharon L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Analgesics, Opioid - pharmacology Carbon Dioxide - metabolism Codeine Cohort Studies Dosage Double-Blind Method Efficacy Female Flicker Fusion Hemodynamics - drug effects Human Humans Liability Male Middle Aged o-Desmethyltramadol (M1) Opioids Oxycodone Oxygen - blood Psychiatry Psychomotor Performance - drug effects Pupil - drug effects Receptors, Opioid, mu - drug effects Reinforcement (Psychology) Self Administration Substance-Related Disorders - psychology Tramadol Tramadol - pharmacology Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!