OVEREXPRESSION OF THIOREDOXIN BINDING PROTEIN (TBP-2) INCREASES OXIDATION SENSITIVITY AND APOPTOSIS IN HUMAN LENS EPITHELIAL CELLS

Thioredoxin (Trx) is an important redox regulator with cytosolic Trx1 and mitochondrial Trx2 isozymes. Trx has multi-physiological functions in cells and its bioavailability is negatively controlled through active site binding to a specific thioredoxin binding protein (TBP-2). This paper describes t...

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Veröffentlicht in:	Free radical biology & medicine 2013-01, Vol.57, p.92-104
Hauptverfasser:	Yu, Yibo, Xing, Kuiyi, Badamas, Rilwan, Kuszynski, Charles A., Wuand, Hongli, Lou, Marjorie F.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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