The topology of the cardiac Na+/Ca2+ exchanger, NCX1

The topology of the plasma membrane Na+/Ca2+ exchanger of cardiac muscle, NCX1, is uncertain. Biochemical analyses have indicated the presence of 9 transmembrane segments (TMSs) whereas the recent crystal structure of a prokaryotic homologue has 10 TMSs. The discrepancy is towards the C-terminus of...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2013-04, Vol.57, p.68-71
Hauptverfasser:	Ren, Xiaoyan, Philipson, Kenneth D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cross-Linking Reagents - chemistry Crosslinking Ethylene Glycols - chemistry Humans Membrane proteins Models, Molecular Moths Na+/Ca2 + exchange Phenanthrolines - chemistry Protein Structure, Secondary Protein Structure, Tertiary Sodium-Calcium Exchanger - chemistry Thiosulfonic Acids - chemistry Topology
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