Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer

Epithelial ovarian cancer (EOC) has an innate susceptibility to become chemoresistant. Up to 30% of patients do not respond to conventional chemotherapy [paclitaxel (Taxol®) in combination with carboplatin] and, of those who have an initial response, many patients relapse. Therefore, an understandin...

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Veröffentlicht in:	The Journal of pathology 2012-04, Vol.226 (5), p.746-755
Hauptverfasser:	Furlong, Fiona, Fitzpatrick, Patricia, O'Toole, Sharon, Phelan, Sine, McGrogan, Barbara, Maguire, Aoife, O'Grady, Anthony, Gallagher, Michael, Prencipe, Maria, McGoldrick, Aloysius, McGettigan, Paul, Brennan, Donal, Sheils, Orla, Martin, Cara, W Kay, Elaine, O'Leary, John, McCann, Amanda
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Carboplatin - administration & dosage Carcinoma, Ovarian Epithelial Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor chemoresistance Chemotherapy, Adjuvant Disease-Free Survival Dose-Response Relationship, Drug Down-Regulation Drug Resistance, Neoplasm - genetics epithelial ovarian cancer Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate MAD2 Mad2 Proteins Medical sciences MicroRNAs - metabolism miR-433 Multivariate Analysis Neoplasm Grading Neoplasm Staging Neoplasms, Cystic, Mucinous, and Serous - genetics Neoplasms, Cystic, Mucinous, and Serous - metabolism Neoplasms, Cystic, Mucinous, and Serous - mortality Neoplasms, Cystic, Mucinous, and Serous - pathology Neoplasms, Cystic, Mucinous, and Serous - therapy Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - mortality Neoplasms, Glandular and Epithelial - pathology Original Papers Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology paclitaxel Paclitaxel - administration & dosage Paraffin Embedding Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proportional Hazards Models Repressor Proteins - genetics Repressor Proteins - metabolism Retrospective Studies Risk Assessment Risk Factors RNA Interference Time Factors Transfection Treatment Outcome Tumors
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