Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs
Aims To assess associations between hypoglycaemia and risk of accidents resulting in hospital visits among people with type 2 diabetes receiving antidiabetes drugs without insulin. Methods People with type 2 diabetes who were not treated with insulin were identified from a US‐based employer claims d...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2013-04, Vol.15 (4), p.335-341 |
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| creator | Signorovitch, J. E. Macaulay, D. Diener, M. Yan, Y. Wu, E. Q. Gruenberger, J.-B. Frier, B. M. |
| description | Aims
To assess associations between hypoglycaemia and risk of accidents resulting in hospital visits among people with type 2 diabetes receiving antidiabetes drugs without insulin.
Methods
People with type 2 diabetes who were not treated with insulin were identified from a US‐based employer claims database (1998–2010). Following initiation of an antidiabetes drug, the occurrence of accidents resulting in hospital visits was compared between people with, and without, claims for hypoglycaemia using multivariable Cox proportional hazard models adjusted for demographics, comorbidities, prior treatments and prior medical service use. Additional analyses were stratified by age 65 years or older.
Results
A total of N = 5582 people with claims for hypoglycaemia and N = 27 910 with no such claims were included. Accidents resulting in hospital visits occurred in 5.5 and 2.8% of people with, and without, hypoglycaemia, respectively. After adjusting for baseline characteristics, hypoglycaemia was associated with significantly increased hazards for any accident [hazard ratio (HR) 1.39, 95% CI 1.21–1.59, p |
| doi_str_mv | 10.1111/dom.12031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3593162</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2920078001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5141-79d6ce3396c09d2388f0890eeeeb88b06dd2305f6434e98cf1e00739afa48d713</originalsourceid><addsrcrecordid>eNp1kU9PFTEUxSdGIggu_AKmiRtdDPTPvE5nY4KoYHyIC43GTdPX3nkUZtqx7Yjz7SkMvKgJd9Pm9ndP7ukpiucE75NcB8b3-4RiRh4VO6TirCSM8se3d1qKBtPt4mmMFxjjion6SbFNGaGE1WyniCfT4NfdpBX0ViHlDFJaWwMuoWDjJbIODeCHDtCVTecoTQMgioxVK0gQUQ9dZ9MYUQqgEpiZct6V1sWxy9PKJbvBTRjXca_YalUX4dnduVt8-_D-69FJuTw7_nh0uCz1glSkrBvDNTDWcI0bQ5kQLc5mINdKiBXmJjfxouUVq6ARuiWAcc0a1apKmJqw3eLNrDuMqx6Mzp6C6uQQbK_CJL2y8t8XZ8_l2v-WbNEwwmkWeHUnEPyvEWKSvY06O1YO_Bhl_mYmCKXiBn35H3rhx-CyvUyRuuIVF02mXs-UDj7GAO1mGYLlTZQyRylvo8zsi7-335D32WXgYAaubAfTw0ry3dnpvWQ5T9iY4M9mQoVLyWtWL-T3z8fyy6cfp2T5823e-xqj2rkS</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317464689</pqid></control><display><type>article</type><title>Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Signorovitch, J. E. ; Macaulay, D. ; Diener, M. ; Yan, Y. ; Wu, E. Q. ; Gruenberger, J.-B. ; Frier, B. M.</creator><creatorcontrib>Signorovitch, J. E. ; Macaulay, D. ; Diener, M. ; Yan, Y. ; Wu, E. Q. ; Gruenberger, J.-B. ; Frier, B. M.</creatorcontrib><description>Aims
To assess associations between hypoglycaemia and risk of accidents resulting in hospital visits among people with type 2 diabetes receiving antidiabetes drugs without insulin.
Methods
People with type 2 diabetes who were not treated with insulin were identified from a US‐based employer claims database (1998–2010). Following initiation of an antidiabetes drug, the occurrence of accidents resulting in hospital visits was compared between people with, and without, claims for hypoglycaemia using multivariable Cox proportional hazard models adjusted for demographics, comorbidities, prior treatments and prior medical service use. Additional analyses were stratified by age 65 years or older.
Results
A total of N = 5582 people with claims for hypoglycaemia and N = 27 910 with no such claims were included. Accidents resulting in hospital visits occurred in 5.5 and 2.8% of people with, and without, hypoglycaemia, respectively. After adjusting for baseline characteristics, hypoglycaemia was associated with significantly increased hazards for any accident [hazard ratio (HR) 1.39, 95% CI 1.21–1.59, p < 0.001], accidental falls (HR 1.36, 95% CI 1.13–1.65, p < 0.001) and motor vehicle accidents (HR 1.82, 95% CI 1.18–2.80, p = 0.007). In age‐stratified analyses, hypoglycaemia was associated with greater hazards of driving‐related accidents in people younger than age 65 and falls in people aged 65 or older.
Conclusions
In people with type 2 diabetes receiving antidiabetes drugs without insulin, hypoglycaemia was associated with a significantly higher risk of accidents resulting in hospital visits, including accidents related to driving and falls.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.12031</identifier><identifier>PMID: 23121373</identifier><identifier>CODEN: DOMEF6</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Accidental Falls - prevention & control ; Accidental Falls - statistics & numerical data ; Accidents ; Accidents, Traffic - prevention & control ; Accidents, Traffic - statistics & numerical data ; Adolescent ; Adult ; Age ; Age Distribution ; Aged ; antidiabetic drug ; Blood Glucose - drug effects ; Comorbidity ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Dipeptidyl-Peptidase IV Inhibitors - adverse effects ; Drug abuse ; Drugs ; Female ; glycaemic control ; Glycated Hemoglobin A - metabolism ; Hospitalization ; Hospitals ; Humans ; Hypoglycemia - blood ; Hypoglycemia - chemically induced ; Hypoglycemia - complications ; Incidence ; Insulin ; Insurance Claim Reporting ; Male ; Metabolism ; Middle Aged ; Morbidity ; Obesity ; Older people ; Original ; Proportional Hazards Models ; Risk Assessment ; Risk Factors ; Studies ; Sulfonylurea Compounds - adverse effects ; Sulfonylurea Compounds - pharmacology ; type 2 diabetes</subject><ispartof>Diabetes, obesity & metabolism, 2013-04, Vol.15 (4), p.335-341</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2012 Blackwell Publishing Ltd.</rights><rights>2013 Blackwell Publishing Ltd</rights><rights>2013 Blackwell Publishing Ltd 2013</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5141-79d6ce3396c09d2388f0890eeeeb88b06dd2305f6434e98cf1e00739afa48d713</citedby><cites>FETCH-LOGICAL-c5141-79d6ce3396c09d2388f0890eeeeb88b06dd2305f6434e98cf1e00739afa48d713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.12031$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.12031$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23121373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Signorovitch, J. E.</creatorcontrib><creatorcontrib>Macaulay, D.</creatorcontrib><creatorcontrib>Diener, M.</creatorcontrib><creatorcontrib>Yan, Y.</creatorcontrib><creatorcontrib>Wu, E. Q.</creatorcontrib><creatorcontrib>Gruenberger, J.-B.</creatorcontrib><creatorcontrib>Frier, B. M.</creatorcontrib><title>Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aims
To assess associations between hypoglycaemia and risk of accidents resulting in hospital visits among people with type 2 diabetes receiving antidiabetes drugs without insulin.
Methods
People with type 2 diabetes who were not treated with insulin were identified from a US‐based employer claims database (1998–2010). Following initiation of an antidiabetes drug, the occurrence of accidents resulting in hospital visits was compared between people with, and without, claims for hypoglycaemia using multivariable Cox proportional hazard models adjusted for demographics, comorbidities, prior treatments and prior medical service use. Additional analyses were stratified by age 65 years or older.
Results
A total of N = 5582 people with claims for hypoglycaemia and N = 27 910 with no such claims were included. Accidents resulting in hospital visits occurred in 5.5 and 2.8% of people with, and without, hypoglycaemia, respectively. After adjusting for baseline characteristics, hypoglycaemia was associated with significantly increased hazards for any accident [hazard ratio (HR) 1.39, 95% CI 1.21–1.59, p < 0.001], accidental falls (HR 1.36, 95% CI 1.13–1.65, p < 0.001) and motor vehicle accidents (HR 1.82, 95% CI 1.18–2.80, p = 0.007). In age‐stratified analyses, hypoglycaemia was associated with greater hazards of driving‐related accidents in people younger than age 65 and falls in people aged 65 or older.
Conclusions
In people with type 2 diabetes receiving antidiabetes drugs without insulin, hypoglycaemia was associated with a significantly higher risk of accidents resulting in hospital visits, including accidents related to driving and falls.</description><subject>Accidental Falls - prevention & control</subject><subject>Accidental Falls - statistics & numerical data</subject><subject>Accidents</subject><subject>Accidents, Traffic - prevention & control</subject><subject>Accidents, Traffic - statistics & numerical data</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>antidiabetic drug</subject><subject>Blood Glucose - drug effects</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Dipeptidyl-Peptidase IV Inhibitors - adverse effects</subject><subject>Drug abuse</subject><subject>Drugs</subject><subject>Female</subject><subject>glycaemic control</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoglycemia - blood</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemia - complications</subject><subject>Incidence</subject><subject>Insulin</subject><subject>Insurance Claim Reporting</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Obesity</subject><subject>Older people</subject><subject>Original</subject><subject>Proportional Hazards Models</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Studies</subject><subject>Sulfonylurea Compounds - adverse effects</subject><subject>Sulfonylurea Compounds - pharmacology</subject><subject>type 2 diabetes</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU9PFTEUxSdGIggu_AKmiRtdDPTPvE5nY4KoYHyIC43GTdPX3nkUZtqx7Yjz7SkMvKgJd9Pm9ndP7ukpiucE75NcB8b3-4RiRh4VO6TirCSM8se3d1qKBtPt4mmMFxjjion6SbFNGaGE1WyniCfT4NfdpBX0ViHlDFJaWwMuoWDjJbIODeCHDtCVTecoTQMgioxVK0gQUQ9dZ9MYUQqgEpiZct6V1sWxy9PKJbvBTRjXca_YalUX4dnduVt8-_D-69FJuTw7_nh0uCz1glSkrBvDNTDWcI0bQ5kQLc5mINdKiBXmJjfxouUVq6ARuiWAcc0a1apKmJqw3eLNrDuMqx6Mzp6C6uQQbK_CJL2y8t8XZ8_l2v-WbNEwwmkWeHUnEPyvEWKSvY06O1YO_Bhl_mYmCKXiBn35H3rhx-CyvUyRuuIVF02mXs-UDj7GAO1mGYLlTZQyRylvo8zsi7-335D32WXgYAaubAfTw0ry3dnpvWQ5T9iY4M9mQoVLyWtWL-T3z8fyy6cfp2T5823e-xqj2rkS</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Signorovitch, J. E.</creator><creator>Macaulay, D.</creator><creator>Diener, M.</creator><creator>Yan, Y.</creator><creator>Wu, E. Q.</creator><creator>Gruenberger, J.-B.</creator><creator>Frier, B. M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>201304</creationdate><title>Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs</title><author>Signorovitch, J. E. ; Macaulay, D. ; Diener, M. ; Yan, Y. ; Wu, E. Q. ; Gruenberger, J.-B. ; Frier, B. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5141-79d6ce3396c09d2388f0890eeeeb88b06dd2305f6434e98cf1e00739afa48d713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accidental Falls - prevention & control</topic><topic>Accidental Falls - statistics & numerical data</topic><topic>Accidents</topic><topic>Accidents, Traffic - prevention & control</topic><topic>Accidents, Traffic - statistics & numerical data</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>antidiabetic drug</topic><topic>Blood Glucose - drug effects</topic><topic>Comorbidity</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Dipeptidyl-Peptidase IV Inhibitors - adverse effects</topic><topic>Drug abuse</topic><topic>Drugs</topic><topic>Female</topic><topic>glycaemic control</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypoglycemia - blood</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemia - complications</topic><topic>Incidence</topic><topic>Insulin</topic><topic>Insurance Claim Reporting</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Obesity</topic><topic>Older people</topic><topic>Original</topic><topic>Proportional Hazards Models</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Studies</topic><topic>Sulfonylurea Compounds - adverse effects</topic><topic>Sulfonylurea Compounds - pharmacology</topic><topic>type 2 diabetes</topic><toplevel>online_resources</toplevel><creatorcontrib>Signorovitch, J. E.</creatorcontrib><creatorcontrib>Macaulay, D.</creatorcontrib><creatorcontrib>Diener, M.</creatorcontrib><creatorcontrib>Yan, Y.</creatorcontrib><creatorcontrib>Wu, E. Q.</creatorcontrib><creatorcontrib>Gruenberger, J.-B.</creatorcontrib><creatorcontrib>Frier, B. M.</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Signorovitch, J. E.</au><au>Macaulay, D.</au><au>Diener, M.</au><au>Yan, Y.</au><au>Wu, E. Q.</au><au>Gruenberger, J.-B.</au><au>Frier, B. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2013-04</date><risdate>2013</risdate><volume>15</volume><issue>4</issue><spage>335</spage><epage>341</epage><pages>335-341</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><coden>DOMEF6</coden><abstract>Aims
To assess associations between hypoglycaemia and risk of accidents resulting in hospital visits among people with type 2 diabetes receiving antidiabetes drugs without insulin.
Methods
People with type 2 diabetes who were not treated with insulin were identified from a US‐based employer claims database (1998–2010). Following initiation of an antidiabetes drug, the occurrence of accidents resulting in hospital visits was compared between people with, and without, claims for hypoglycaemia using multivariable Cox proportional hazard models adjusted for demographics, comorbidities, prior treatments and prior medical service use. Additional analyses were stratified by age 65 years or older.
Results
A total of N = 5582 people with claims for hypoglycaemia and N = 27 910 with no such claims were included. Accidents resulting in hospital visits occurred in 5.5 and 2.8% of people with, and without, hypoglycaemia, respectively. After adjusting for baseline characteristics, hypoglycaemia was associated with significantly increased hazards for any accident [hazard ratio (HR) 1.39, 95% CI 1.21–1.59, p < 0.001], accidental falls (HR 1.36, 95% CI 1.13–1.65, p < 0.001) and motor vehicle accidents (HR 1.82, 95% CI 1.18–2.80, p = 0.007). In age‐stratified analyses, hypoglycaemia was associated with greater hazards of driving‐related accidents in people younger than age 65 and falls in people aged 65 or older.
Conclusions
In people with type 2 diabetes receiving antidiabetes drugs without insulin, hypoglycaemia was associated with a significantly higher risk of accidents resulting in hospital visits, including accidents related to driving and falls.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23121373</pmid><doi>10.1111/dom.12031</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Accidental Falls - prevention & control Accidental Falls - statistics & numerical data Accidents Accidents, Traffic - prevention & control Accidents, Traffic - statistics & numerical data Adolescent Adult Age Age Distribution Aged antidiabetic drug Blood Glucose - drug effects Comorbidity Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Dipeptidyl-Peptidase IV Inhibitors - adverse effects Drug abuse Drugs Female glycaemic control Glycated Hemoglobin A - metabolism Hospitalization Hospitals Humans Hypoglycemia - blood Hypoglycemia - chemically induced Hypoglycemia - complications Incidence Insulin Insurance Claim Reporting Male Metabolism Middle Aged Morbidity Obesity Older people Original Proportional Hazards Models Risk Assessment Risk Factors Studies Sulfonylurea Compounds - adverse effects Sulfonylurea Compounds - pharmacology type 2 diabetes |
| title | Hypoglycaemia and accident risk in people with type 2 diabetes mellitus treated with non-insulin antidiabetes drugs |
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