Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving

Rationale and objectives Responding to heroin cues progressively increases after cessation of heroin self-administration (incubation of heroin craving). We investigated whether this incubation is associated with time-dependent changes in brain-derived neurotrophic factor (BDNF) and methyl-CpG bindin...

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Veröffentlicht in:	Psychopharmacologia 2012-12, Vol.224 (4), p.559-571
Hauptverfasser:	Theberge, Florence R. M., Pickens, Charles L., Goldart, Evan, Fanous, Sanya, Hope, Bruce T., Liu, Qing-Rong, Shaham, Yavin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral decision theory Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain-Derived Neurotrophic Factor Cocaine Cues Dose-Response Relationship, Drug Drug addiction Gene Expression Regulation - drug effects Heroin Heroin - administration & dosage Heroin Dependence - psychology Male Medical sciences Messenger RNA Methyl-CpG-Binding Protein 2 - genetics Naloxone - administration & dosage Naloxone - pharmacology Narcotic Antagonists - administration & dosage Narcotic Antagonists - pharmacology Neurosciences Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Original Investigation Pharmacology/Toxicology Protein binding Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Receptor, trkB - genetics Receptors, Opioid, mu - genetics RNA, Messenger - metabolism Self Administration Time Factors
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