Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

Tumour-derived mutant p53 proteins promote invasion, in part, by enhancing Rab coupling protein (RCP)-dependent receptor recycling. Here we identified MET as an RCP-binding protein and showed that mutant p53 promoted MET recycling. Mutant p53-expressing cells were more sensitive to hepatocyte growth...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2013-03, Vol.32 (10), p.1252-1265
Hauptverfasser:	Muller, P A J, Trinidad, A G, Timpson, P, Morton, J P, Zanivan, S, van den Berghe, P V E, Nixon, C, Karim, S A, Caswell, P T, Noll, J E, Coffill, C R, Lane, D P, Sansom, O J, Neilsen, P M, Norman, J C, Vousden, K H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/322 631/80/84/2336 631/80/86 Animals Apoptosis Cancer cells Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell adhesion & migration Cell Biology Cell Movement Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology HCT116 Cells HT29 Cells Human Genetics Humans Internal Medicine Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health Metastasis Mice Mutation Neoplasm Invasiveness Oncology Original original-article Phosphorylation Proteins Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Signal Transduction Transcription Factors - metabolism Transfection Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins - metabolism Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!