Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells
MicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-6 |
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| creator | Sanchez-Muñoz, Fausto Gómez-García, Lorena Terrazas, Luis I. Pérez-Miranda, Magaly Mejía-Domínguez, Ana M. Ledesma-Soto, Yadira Bojalil, Rafael |
| description | MicroRNAs have emerged as key regulators of immune responses. They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells. We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response. This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host. |
| doi_str_mv | 10.1155/2013/972506 |
| format | Article |
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They influence immune cells' function and probably the outcome of several infections. Currently, it is largely unknown if helminth parasites and their antigens modify host microRNAs expression. The aim of this study was to explore if excreted/secreted antigens of Taenia crassiceps regulate LPS-induced miRNAs expression in human Dendritic Cells. We found that these antigens repressed LPS-let-7i induction but not mir-146a or mir-155 and this correlates with a diminished inflammatory response. This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/972506</identifier><identifier>PMID: 23509825</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antigens, Helminth - immunology ; Cytokines - immunology ; Dendritic cells ; Dendritic Cells - immunology ; Dendritic Cells - metabolism ; Echinococcosis - immunology ; Gene Expression Regulation ; Gene Silencing ; Humans ; Lipopolysaccharides ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Monocytes - immunology ; Taenia - immunology ; Taenia crassiceps</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-6</ispartof><rights>Copyright © 2013 Luis I. Terrazas et al.</rights><rights>Copyright © 2013 Luis I. Terrazas et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-5d925712e2a485d0c1545079a57841b7c8bfdfa2d1438666b8ef63b1c2e6da243</citedby><cites>FETCH-LOGICAL-c472t-5d925712e2a485d0c1545079a57841b7c8bfdfa2d1438666b8ef63b1c2e6da243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591137/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591137/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23509825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rodríguez-Sosa, Miriam</contributor><creatorcontrib>Sanchez-Muñoz, Fausto</creatorcontrib><creatorcontrib>Gómez-García, Lorena</creatorcontrib><creatorcontrib>Terrazas, Luis I.</creatorcontrib><creatorcontrib>Pérez-Miranda, Magaly</creatorcontrib><creatorcontrib>Mejía-Domínguez, Ana M.</creatorcontrib><creatorcontrib>Ledesma-Soto, Yadira</creatorcontrib><creatorcontrib>Bojalil, Rafael</creatorcontrib><title>Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>MicroRNAs have emerged as key regulators of immune responses. 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This let-7i downregulation in Dendritic Cells constitutes a novel feature of the modulatory activity that helminth-derived antigens exert on their host.</description><subject>Animals</subject><subject>Antigens, Helminth - immunology</subject><subject>Cytokines - immunology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Echinococcosis - immunology</subject><subject>Gene Expression Regulation</subject><subject>Gene Silencing</subject><subject>Humans</subject><subject>Lipopolysaccharides</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Monocytes - immunology</subject><subject>Taenia - immunology</subject><subject>Taenia crassiceps</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQxSNERau2J-7IRwQK628nF6Rq27KVVoBaOFuOPekaJc4SO0Cv_OV4m3ZVTjCXmdH89DRPryheEvyOECEWFBO2qBUVWD4rjigjvJSEk-f7mbHD4jTGbzhXRSSu5YvikDKB64qKo-L3Crreh7RBF7_sCAnc4gbmAZ2F5G8hRHQN2xFizMh990NAQ4vWn2_Kq-Amm9E1pFJ51EwJfRwS6v11Sbg0yAQ3L0IgH9Bq6k1A5xDc6JO3aAldF0-Kg9Z0EU4f-nHx9fLiy3JVrj99uFqerUvLFU2lcDUVilCghlfCYUsEF1jVRqiKk0bZqmlda6gjnFVSyqaCVrKGWArSGcrZcfF-1t1OTQ_OQkij6fR29L0Z7_RgvP77EvxG3w4_NBM1IUxlgdcPAuPwfYKYdO-jzRZMgGGKOjvOHwlW43-jjFS4FrXaoW9n1I5DjCO0-48I1ruM9S5jPWec6VdPTezZx0Qz8GYGNj4489P_nxpkBFrzBGYZrtgfHEm2SA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Sanchez-Muñoz, Fausto</creator><creator>Gómez-García, Lorena</creator><creator>Terrazas, Luis I.</creator><creator>Pérez-Miranda, Magaly</creator><creator>Mejía-Domínguez, Ana M.</creator><creator>Ledesma-Soto, Yadira</creator><creator>Bojalil, Rafael</creator><general>Hindawi Publishing Corporation</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20130101</creationdate><title>Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells</title><author>Sanchez-Muñoz, Fausto ; 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| subjects | Animals Antigens, Helminth - immunology Cytokines - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Echinococcosis - immunology Gene Expression Regulation Gene Silencing Humans Lipopolysaccharides MicroRNAs - genetics MicroRNAs - metabolism Monocytes - immunology Taenia - immunology Taenia crassiceps |
| title | Helminth Excreted/Secreted Antigens Repress Expression of LPS-Induced Let-7i but Not miR-146a and miR-155 in Human Dendritic Cells |
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