CD4 + CD25 + FOXP3 + Treg Cells Induced by rSSP4 Derived from T. cruzi Amastigotes Increase Parasitemia in an Experimental Chagas Disease Model

Currently, there is a considerable controversy over the participation of Treg cells during Trypanosoma cruzi infection, the main point being whether these cells play a negative or a positive role. In this work, we found that the adoptive transfer of CD4+CD25+FOXP3+ T cells from rSSP4- (a recombinant...

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Veröffentlicht in:	BioMed research international 2013-01, Vol.2013 (2013), p.1-10
Hauptverfasser:	Satoskar, A. R., Rosales-García, V. H., Rosales-Encina, José Luis, Flores-García, Y., Talamás-Rohana, Patricia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Cell Proliferation Chagas Disease - immunology Disease Models, Animal Female Forkhead Transcription Factors - metabolism Heart - parasitology Inflammation - parasitology Mice Mice, Inbred BALB C Myocardium - metabolism Protozoan Proteins - chemistry Recombinant Proteins - chemistry Spleen - cytology Spleen - immunology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - parasitology Trypanosoma cruzi
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