Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties

The agents responsible for transmissible spongiform encephalopathies (TSEs), or prion diseases, contain as a major component PrP Sc , an abnormal conformer of the host glycoprotein PrP C . TSE agents are distinguished by differences in phenotypic properties in the host, which nevertheless can contai...

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Veröffentlicht in:	The EMBO journal 2013-03, Vol.32 (5), p.756-769
Hauptverfasser:	Cancellotti, Enrico, Mahal, Sukhvir P, Somerville, Robert, Diack, Abigail, Brown, Deborah, Piccardo, Pedro, Weissmann, Charles, Manson, Jean C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Brain - virology Cells, Cultured EMBO27 EMBO31 Female Glycoproteins Glycosylation Immunoenzyme Techniques Male Mice Mice, Inbred C57BL Mice, Transgenic Molecular biology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - virology phenotypic change Polysaccharides - metabolism prion Prion Diseases - metabolism Prion Diseases - transmission Prion Diseases - virology Protein Processing, Post-Translational PrPSc Proteins - genetics PrPSc Proteins - metabolism PrPSc Proteins - pathogenicity Spongiform encephalopathies transmissible spongiform encephalopathy Virus Replication
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