Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings
Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically...
Gespeichert in:
| Veröffentlicht in: | Biological psychiatry (1969) 2008-10, Vol.64 (7), p.571-576 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 576 |
|---|---|
| container_issue | 7 |
| container_start_page | 571 |
| container_title | Biological psychiatry (1969) |
| container_volume | 64 |
| creator | Zhou, Kaixin Asherson, Philip Sham, Pak Franke, Barbara Anney, Richard J.L. Buitelaar, Jan Ebstein, Richard Gill, Michael Brookes, Keeley Buschgens, Cathelijne Campbell, Desmond Chen, Wai Christiansen, Hanna Fliers, Ellen Gabriëls, Isabel Johansson, Lena Marco, Rafaela Mulas, Fernando Müller, Ueli Mulligan, Aisling Neale, Benjamin M. Rijsdijk, Fruhling Rommelse, Nanda Uebel, Henrik Psychogiou, Lamprini Xu, Xiaohui Banaschewski, Tobias Sonuga-Barke, Edmund Eisenberg, Jacques Manor, Iris Miranda, Ana Oades, Robert D. Roeyers, Herbert Rothenberger, Aribert Sergeant, Joseph Steinhausen, Hans-Christoph Taylor, Eric Thompson, Margaret Faraone, Stephen V. |
| description | Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL).
A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score.
A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait.
These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia. |
| doi_str_mv | 10.1016/j.biopsych.2008.02.024 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006322308003375</els_id><sourcerecordid>69523075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-c7dc834f3b366570819f2961c75982706f300d0421783a91615dfa869bc8acea3</originalsourceid><addsrcrecordid>eNqFkU9vEzEQxS0EoqHwFSpf4Lap_-x67QuiSoEgReLQcrYcrzeZsGsvthMp376OEgqckEYajfybN09-CN1QMqeEitvdfA1hSke7nTNC5JywUvULNKOy5RWrCXuJZoQQUXHG-BV6k9KujC1j9DW6orLmqmnJDO1W4H-ajcM54MU2hjGkMDpMJy5wHyK-y9n5DMFX964HC_l2eZxcNDbDAfIR30MKsXMRP0YDOWHw-MFuQxiw8R1enrQeXM7gN-ktetWbIbl3l36Nfnz5_LhYVqvvX78t7laVrZXKlW07K3nd8zUXoniUVPVMCWrbRknWEtFzQjpSM9pKbhQVtOl6I4VaW2msM_wafTzrTvv16Dpb_Ecz6CnCaOJRBwP63xcPW70JB80bqZSUReDDRSCGX3uXsh4hWTcMxruwT1qohnHSNgUUZ9DGkFJ0_fMRSvQpJr3Tv2PSp5g0YaXqsnjzt8U_a5dcCvD-AphkzdBH4y2kZ46RwlAqCvfpzLnyoQdwUScLzlvXQXQ26y7A_7w8AeTqtX4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69523075</pqid></control><display><type>article</type><title>Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Zhou, Kaixin ; Asherson, Philip ; Sham, Pak ; Franke, Barbara ; Anney, Richard J.L. ; Buitelaar, Jan ; Ebstein, Richard ; Gill, Michael ; Brookes, Keeley ; Buschgens, Cathelijne ; Campbell, Desmond ; Chen, Wai ; Christiansen, Hanna ; Fliers, Ellen ; Gabriëls, Isabel ; Johansson, Lena ; Marco, Rafaela ; Mulas, Fernando ; Müller, Ueli ; Mulligan, Aisling ; Neale, Benjamin M. ; Rijsdijk, Fruhling ; Rommelse, Nanda ; Uebel, Henrik ; Psychogiou, Lamprini ; Xu, Xiaohui ; Banaschewski, Tobias ; Sonuga-Barke, Edmund ; Eisenberg, Jacques ; Manor, Iris ; Miranda, Ana ; Oades, Robert D. ; Roeyers, Herbert ; Rothenberger, Aribert ; Sergeant, Joseph ; Steinhausen, Hans-Christoph ; Taylor, Eric ; Thompson, Margaret ; Faraone, Stephen V.</creator><creatorcontrib>Zhou, Kaixin ; Asherson, Philip ; Sham, Pak ; Franke, Barbara ; Anney, Richard J.L. ; Buitelaar, Jan ; Ebstein, Richard ; Gill, Michael ; Brookes, Keeley ; Buschgens, Cathelijne ; Campbell, Desmond ; Chen, Wai ; Christiansen, Hanna ; Fliers, Ellen ; Gabriëls, Isabel ; Johansson, Lena ; Marco, Rafaela ; Mulas, Fernando ; Müller, Ueli ; Mulligan, Aisling ; Neale, Benjamin M. ; Rijsdijk, Fruhling ; Rommelse, Nanda ; Uebel, Henrik ; Psychogiou, Lamprini ; Xu, Xiaohui ; Banaschewski, Tobias ; Sonuga-Barke, Edmund ; Eisenberg, Jacques ; Manor, Iris ; Miranda, Ana ; Oades, Robert D. ; Roeyers, Herbert ; Rothenberger, Aribert ; Sergeant, Joseph ; Steinhausen, Hans-Christoph ; Taylor, Eric ; Thompson, Margaret ; Faraone, Stephen V.</creatorcontrib><description>Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL).
A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score.
A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait.
These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2008.02.024</identifier><identifier>PMID: 18439570</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ADHD ; Adolescent ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit disorders. Hyperactivity ; Biological and medical sciences ; Child ; Child clinical studies ; Child, Preschool ; Chromosomes, Human, Pair 1 - genetics ; Dyslexia - diagnosis ; Dyslexia - epidemiology ; Dyslexia - genetics ; Female ; Genetic Linkage - genetics ; Humans ; linkage ; Male ; Medical sciences ; Phenotype ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; QTL ; Schools ; Social Environment ; White People - genetics</subject><ispartof>Biological psychiatry (1969), 2008-10, Vol.64 (7), p.571-576</ispartof><rights>2008 Society of Biological Psychiatry</rights><rights>2008 INIST-CNRS</rights><rights>2008 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-c7dc834f3b366570819f2961c75982706f300d0421783a91615dfa869bc8acea3</citedby><cites>FETCH-LOGICAL-c499t-c7dc834f3b366570819f2961c75982706f300d0421783a91615dfa869bc8acea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322308003375$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20703116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18439570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Kaixin</creatorcontrib><creatorcontrib>Asherson, Philip</creatorcontrib><creatorcontrib>Sham, Pak</creatorcontrib><creatorcontrib>Franke, Barbara</creatorcontrib><creatorcontrib>Anney, Richard J.L.</creatorcontrib><creatorcontrib>Buitelaar, Jan</creatorcontrib><creatorcontrib>Ebstein, Richard</creatorcontrib><creatorcontrib>Gill, Michael</creatorcontrib><creatorcontrib>Brookes, Keeley</creatorcontrib><creatorcontrib>Buschgens, Cathelijne</creatorcontrib><creatorcontrib>Campbell, Desmond</creatorcontrib><creatorcontrib>Chen, Wai</creatorcontrib><creatorcontrib>Christiansen, Hanna</creatorcontrib><creatorcontrib>Fliers, Ellen</creatorcontrib><creatorcontrib>Gabriëls, Isabel</creatorcontrib><creatorcontrib>Johansson, Lena</creatorcontrib><creatorcontrib>Marco, Rafaela</creatorcontrib><creatorcontrib>Mulas, Fernando</creatorcontrib><creatorcontrib>Müller, Ueli</creatorcontrib><creatorcontrib>Mulligan, Aisling</creatorcontrib><creatorcontrib>Neale, Benjamin M.</creatorcontrib><creatorcontrib>Rijsdijk, Fruhling</creatorcontrib><creatorcontrib>Rommelse, Nanda</creatorcontrib><creatorcontrib>Uebel, Henrik</creatorcontrib><creatorcontrib>Psychogiou, Lamprini</creatorcontrib><creatorcontrib>Xu, Xiaohui</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Sonuga-Barke, Edmund</creatorcontrib><creatorcontrib>Eisenberg, Jacques</creatorcontrib><creatorcontrib>Manor, Iris</creatorcontrib><creatorcontrib>Miranda, Ana</creatorcontrib><creatorcontrib>Oades, Robert D.</creatorcontrib><creatorcontrib>Roeyers, Herbert</creatorcontrib><creatorcontrib>Rothenberger, Aribert</creatorcontrib><creatorcontrib>Sergeant, Joseph</creatorcontrib><creatorcontrib>Steinhausen, Hans-Christoph</creatorcontrib><creatorcontrib>Taylor, Eric</creatorcontrib><creatorcontrib>Thompson, Margaret</creatorcontrib><creatorcontrib>Faraone, Stephen V.</creatorcontrib><title>Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL).
A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score.
A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait.
These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.</description><subject>ADHD</subject><subject>Adolescent</subject><subject>Attention Deficit Disorder with Hyperactivity - diagnosis</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Attention deficit disorders. Hyperactivity</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child, Preschool</subject><subject>Chromosomes, Human, Pair 1 - genetics</subject><subject>Dyslexia - diagnosis</subject><subject>Dyslexia - epidemiology</subject><subject>Dyslexia - genetics</subject><subject>Female</subject><subject>Genetic Linkage - genetics</subject><subject>Humans</subject><subject>linkage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>QTL</subject><subject>Schools</subject><subject>Social Environment</subject><subject>White People - genetics</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EoqHwFSpf4Lap_-x67QuiSoEgReLQcrYcrzeZsGsvthMp376OEgqckEYajfybN09-CN1QMqeEitvdfA1hSke7nTNC5JywUvULNKOy5RWrCXuJZoQQUXHG-BV6k9KujC1j9DW6orLmqmnJDO1W4H-ajcM54MU2hjGkMDpMJy5wHyK-y9n5DMFX964HC_l2eZxcNDbDAfIR30MKsXMRP0YDOWHw-MFuQxiw8R1enrQeXM7gN-ktetWbIbl3l36Nfnz5_LhYVqvvX78t7laVrZXKlW07K3nd8zUXoniUVPVMCWrbRknWEtFzQjpSM9pKbhQVtOl6I4VaW2msM_wafTzrTvv16Dpb_Ecz6CnCaOJRBwP63xcPW70JB80bqZSUReDDRSCGX3uXsh4hWTcMxruwT1qohnHSNgUUZ9DGkFJ0_fMRSvQpJr3Tv2PSp5g0YaXqsnjzt8U_a5dcCvD-AphkzdBH4y2kZ46RwlAqCvfpzLnyoQdwUScLzlvXQXQ26y7A_7w8AeTqtX4</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Zhou, Kaixin</creator><creator>Asherson, Philip</creator><creator>Sham, Pak</creator><creator>Franke, Barbara</creator><creator>Anney, Richard J.L.</creator><creator>Buitelaar, Jan</creator><creator>Ebstein, Richard</creator><creator>Gill, Michael</creator><creator>Brookes, Keeley</creator><creator>Buschgens, Cathelijne</creator><creator>Campbell, Desmond</creator><creator>Chen, Wai</creator><creator>Christiansen, Hanna</creator><creator>Fliers, Ellen</creator><creator>Gabriëls, Isabel</creator><creator>Johansson, Lena</creator><creator>Marco, Rafaela</creator><creator>Mulas, Fernando</creator><creator>Müller, Ueli</creator><creator>Mulligan, Aisling</creator><creator>Neale, Benjamin M.</creator><creator>Rijsdijk, Fruhling</creator><creator>Rommelse, Nanda</creator><creator>Uebel, Henrik</creator><creator>Psychogiou, Lamprini</creator><creator>Xu, Xiaohui</creator><creator>Banaschewski, Tobias</creator><creator>Sonuga-Barke, Edmund</creator><creator>Eisenberg, Jacques</creator><creator>Manor, Iris</creator><creator>Miranda, Ana</creator><creator>Oades, Robert D.</creator><creator>Roeyers, Herbert</creator><creator>Rothenberger, Aribert</creator><creator>Sergeant, Joseph</creator><creator>Steinhausen, Hans-Christoph</creator><creator>Taylor, Eric</creator><creator>Thompson, Margaret</creator><creator>Faraone, Stephen V.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081001</creationdate><title>Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings</title><author>Zhou, Kaixin ; Asherson, Philip ; Sham, Pak ; Franke, Barbara ; Anney, Richard J.L. ; Buitelaar, Jan ; Ebstein, Richard ; Gill, Michael ; Brookes, Keeley ; Buschgens, Cathelijne ; Campbell, Desmond ; Chen, Wai ; Christiansen, Hanna ; Fliers, Ellen ; Gabriëls, Isabel ; Johansson, Lena ; Marco, Rafaela ; Mulas, Fernando ; Müller, Ueli ; Mulligan, Aisling ; Neale, Benjamin M. ; Rijsdijk, Fruhling ; Rommelse, Nanda ; Uebel, Henrik ; Psychogiou, Lamprini ; Xu, Xiaohui ; Banaschewski, Tobias ; Sonuga-Barke, Edmund ; Eisenberg, Jacques ; Manor, Iris ; Miranda, Ana ; Oades, Robert D. ; Roeyers, Herbert ; Rothenberger, Aribert ; Sergeant, Joseph ; Steinhausen, Hans-Christoph ; Taylor, Eric ; Thompson, Margaret ; Faraone, Stephen V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-c7dc834f3b366570819f2961c75982706f300d0421783a91615dfa869bc8acea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ADHD</topic><topic>Adolescent</topic><topic>Attention Deficit Disorder with Hyperactivity - diagnosis</topic><topic>Attention Deficit Disorder with Hyperactivity - epidemiology</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Attention deficit disorders. Hyperactivity</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child, Preschool</topic><topic>Chromosomes, Human, Pair 1 - genetics</topic><topic>Dyslexia - diagnosis</topic><topic>Dyslexia - epidemiology</topic><topic>Dyslexia - genetics</topic><topic>Female</topic><topic>Genetic Linkage - genetics</topic><topic>Humans</topic><topic>linkage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>QTL</topic><topic>Schools</topic><topic>Social Environment</topic><topic>White People - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Kaixin</creatorcontrib><creatorcontrib>Asherson, Philip</creatorcontrib><creatorcontrib>Sham, Pak</creatorcontrib><creatorcontrib>Franke, Barbara</creatorcontrib><creatorcontrib>Anney, Richard J.L.</creatorcontrib><creatorcontrib>Buitelaar, Jan</creatorcontrib><creatorcontrib>Ebstein, Richard</creatorcontrib><creatorcontrib>Gill, Michael</creatorcontrib><creatorcontrib>Brookes, Keeley</creatorcontrib><creatorcontrib>Buschgens, Cathelijne</creatorcontrib><creatorcontrib>Campbell, Desmond</creatorcontrib><creatorcontrib>Chen, Wai</creatorcontrib><creatorcontrib>Christiansen, Hanna</creatorcontrib><creatorcontrib>Fliers, Ellen</creatorcontrib><creatorcontrib>Gabriëls, Isabel</creatorcontrib><creatorcontrib>Johansson, Lena</creatorcontrib><creatorcontrib>Marco, Rafaela</creatorcontrib><creatorcontrib>Mulas, Fernando</creatorcontrib><creatorcontrib>Müller, Ueli</creatorcontrib><creatorcontrib>Mulligan, Aisling</creatorcontrib><creatorcontrib>Neale, Benjamin M.</creatorcontrib><creatorcontrib>Rijsdijk, Fruhling</creatorcontrib><creatorcontrib>Rommelse, Nanda</creatorcontrib><creatorcontrib>Uebel, Henrik</creatorcontrib><creatorcontrib>Psychogiou, Lamprini</creatorcontrib><creatorcontrib>Xu, Xiaohui</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Sonuga-Barke, Edmund</creatorcontrib><creatorcontrib>Eisenberg, Jacques</creatorcontrib><creatorcontrib>Manor, Iris</creatorcontrib><creatorcontrib>Miranda, Ana</creatorcontrib><creatorcontrib>Oades, Robert D.</creatorcontrib><creatorcontrib>Roeyers, Herbert</creatorcontrib><creatorcontrib>Rothenberger, Aribert</creatorcontrib><creatorcontrib>Sergeant, Joseph</creatorcontrib><creatorcontrib>Steinhausen, Hans-Christoph</creatorcontrib><creatorcontrib>Taylor, Eric</creatorcontrib><creatorcontrib>Thompson, Margaret</creatorcontrib><creatorcontrib>Faraone, Stephen V.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Kaixin</au><au>Asherson, Philip</au><au>Sham, Pak</au><au>Franke, Barbara</au><au>Anney, Richard J.L.</au><au>Buitelaar, Jan</au><au>Ebstein, Richard</au><au>Gill, Michael</au><au>Brookes, Keeley</au><au>Buschgens, Cathelijne</au><au>Campbell, Desmond</au><au>Chen, Wai</au><au>Christiansen, Hanna</au><au>Fliers, Ellen</au><au>Gabriëls, Isabel</au><au>Johansson, Lena</au><au>Marco, Rafaela</au><au>Mulas, Fernando</au><au>Müller, Ueli</au><au>Mulligan, Aisling</au><au>Neale, Benjamin M.</au><au>Rijsdijk, Fruhling</au><au>Rommelse, Nanda</au><au>Uebel, Henrik</au><au>Psychogiou, Lamprini</au><au>Xu, Xiaohui</au><au>Banaschewski, Tobias</au><au>Sonuga-Barke, Edmund</au><au>Eisenberg, Jacques</au><au>Manor, Iris</au><au>Miranda, Ana</au><au>Oades, Robert D.</au><au>Roeyers, Herbert</au><au>Rothenberger, Aribert</au><au>Sergeant, Joseph</au><au>Steinhausen, Hans-Christoph</au><au>Taylor, Eric</au><au>Thompson, Margaret</au><au>Faraone, Stephen V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>64</volume><issue>7</issue><spage>571</spage><epage>576</epage><pages>571-576</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL).
A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score.
A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p < .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait.
These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18439570</pmid><doi>10.1016/j.biopsych.2008.02.024</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-3223 |
| ispartof | Biological psychiatry (1969), 2008-10, Vol.64 (7), p.571-576 |
| issn | 0006-3223 1873-2402 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589988 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | ADHD Adolescent Attention Deficit Disorder with Hyperactivity - diagnosis Attention Deficit Disorder with Hyperactivity - epidemiology Attention Deficit Disorder with Hyperactivity - genetics Attention deficit disorders. Hyperactivity Biological and medical sciences Child Child clinical studies Child, Preschool Chromosomes, Human, Pair 1 - genetics Dyslexia - diagnosis Dyslexia - epidemiology Dyslexia - genetics Female Genetic Linkage - genetics Humans linkage Male Medical sciences Phenotype Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry QTL Schools Social Environment White People - genetics |
| title | Linkage to Chromosome 1p36 for Attention-Deficit/Hyperactivity Disorder Traits in School and Home Settings |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Linkage%20to%20Chromosome%201p36%20for%20Attention-Deficit/Hyperactivity%20Disorder%20Traits%20in%20School%20and%20Home%20Settings&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=Zhou,%20Kaixin&rft.date=2008-10-01&rft.volume=64&rft.issue=7&rft.spage=571&rft.epage=576&rft.pages=571-576&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/j.biopsych.2008.02.024&rft_dat=%3Cproquest_pubme%3E69523075%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69523075&rft_id=info:pmid/18439570&rft_els_id=S0006322308003375&rfr_iscdi=true |