Tyrosyl Phosphorylated PAK1 Regulates Breast Cancer Cell Motility in Response to Prolactin through Filamin A

The p21-activated serine-threonine kinase (PAK1) is activated by small GTPase-dependent and -independent mechanisms and regulates cell motility. Both PAK1 and the hormone prolactin (PRL) have been implicated in breast cancer by numerous studies. We have previously shown that the PRL-activated tyrosi...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2013-03, Vol.27 (3), p.455-465
Hauptverfasser:	Hammer, Alan, Rider, Leah, Oladimeji, Peter, Cook, Leslie, Li, Quanwen, Mattingly, Raymond R, Diakonova, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - enzymology Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Clone Cells Contractile Proteins - metabolism Female Filamins Green Fluorescent Proteins - metabolism Humans Janus Kinase 2 - metabolism Microfilament Proteins - metabolism Models, Biological Mutant Proteins - metabolism Original Research p21-Activated Kinases - metabolism Phosphorylation - drug effects Phosphoserine - metabolism Phosphotyrosine - metabolism Prolactin - pharmacology
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