Big Effects of Small RNAs: A Review of MicroRNAs in Anxiety
Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their...
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| Veröffentlicht in: | Molecular neurobiology 2013-04, Vol.47 (2), p.726-739 |
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| container_title | Molecular neurobiology |
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| creator | Malan-Müller, Stefanie Hemmings, Sîan Megan Joanna Seedat, Soraya |
| description | Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding to target messenger RNAs (mRNAs) and hindering translation or accelerating degradation. Considering their role in neuronal differentiation and synaptic plasticity, miRNAs have opened up new investigative avenues in the aetiology and treatment of anxiety disorders. In this review, we provide a thorough analysis of miRNAs, their targets and their functions in the central nervous system (CNS), focusing on their role in anxiety disorders. The involvement of miRNAs in CNS functions (such as neurogenesis, neurite outgrowth, synaptogenesis and synaptic and neural plasticity) and their intricate regulatory role under stressful conditions strongly support their importance in the aetiology of anxiety disorders. Furthermore, miRNAs could provide new avenues for the development of therapeutic targets in anxiety disorders. |
| doi_str_mv | 10.1007/s12035-012-8374-6 |
| format | Article |
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MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding to target messenger RNAs (mRNAs) and hindering translation or accelerating degradation. Considering their role in neuronal differentiation and synaptic plasticity, miRNAs have opened up new investigative avenues in the aetiology and treatment of anxiety disorders. In this review, we provide a thorough analysis of miRNAs, their targets and their functions in the central nervous system (CNS), focusing on their role in anxiety disorders. The involvement of miRNAs in CNS functions (such as neurogenesis, neurite outgrowth, synaptogenesis and synaptic and neural plasticity) and their intricate regulatory role under stressful conditions strongly support their importance in the aetiology of anxiety disorders. Furthermore, miRNAs could provide new avenues for the development of therapeutic targets in anxiety disorders.</description><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - genetics</subject><subject>Anxiety - metabolism</subject><subject>Anxiety - therapy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Gene Targeting - trends</subject><subject>Genetic Therapy - trends</subject><subject>Humans</subject><subject>MicroRNAs - chemistry</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - physiology</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neurosciences</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtLxDAQx4Mouj4-gBfp0Us1k1cTBWEVX-AD1HvIZidrpNtq013129uyKnoRTwMzv_yYzJ-QbaB7QGmxn4BRLnMKLNe8ELlaIgOQ0uQAmi2TAdWG54USeo2sp_REKWNAi1WyxjhICgUdkMPjOMlOQ0DfpqwO2f3UlWV2dzNMB9kwu8N5xNe-fx19U_ftLFbZsHqL2L5vkpXgyoRbn3WDPJydPpxc5Fe355cnw6vcSwFtjs5x5wtugnfaaBTec43eO2WMoqYwTo2pN8IgE1oKrkbFOIykD2qEAZFvkKOF9nk2muLYY9U2rrTPTZy65t3WLtrfkyo-2kk9t1xqo5jqBLufgqZ-mWFq7TQmj2XpKqxnyQJnXAMF-h8UJHAhGHQoLNDuMCk1GL43Amr7eOwiHtvFY_t4bK_f-fmV7xdfeXQAWwCpG1UTbOxTPWuq7rp_WD8AGRiZtw</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Malan-Müller, Stefanie</creator><creator>Hemmings, Sîan Megan Joanna</creator><creator>Seedat, Soraya</creator><general>Humana Press Inc</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20130401</creationdate><title>Big Effects of Small RNAs: A Review of MicroRNAs in Anxiety</title><author>Malan-Müller, Stefanie ; Hemmings, Sîan Megan Joanna ; Seedat, Soraya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-eaa3ac739fca898e4cc38ecca69960979a6d0c949e2485436b7dfb5cf6befee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - genetics</topic><topic>Anxiety - metabolism</topic><topic>Anxiety - therapy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Gene Targeting - trends</topic><topic>Genetic Therapy - trends</topic><topic>Humans</topic><topic>MicroRNAs - chemistry</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - physiology</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neuronal Plasticity - genetics</topic><topic>Neurosciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malan-Müller, Stefanie</creatorcontrib><creatorcontrib>Hemmings, Sîan Megan Joanna</creatorcontrib><creatorcontrib>Seedat, Soraya</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malan-Müller, Stefanie</au><au>Hemmings, Sîan Megan Joanna</au><au>Seedat, Soraya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Big Effects of Small RNAs: A Review of MicroRNAs in Anxiety</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>47</volume><issue>2</issue><spage>726</spage><epage>739</epage><pages>726-739</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. 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| subjects | Animals Anxiety Anxiety - genetics Anxiety - metabolism Anxiety - therapy Biomedical and Life Sciences Biomedicine Cell Biology Gene Targeting - trends Genetic Therapy - trends Humans MicroRNAs - chemistry MicroRNAs - genetics MicroRNAs - physiology Neurobiology Neurology Neuronal Plasticity - genetics Neurosciences |
| title | Big Effects of Small RNAs: A Review of MicroRNAs in Anxiety |
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