Increasing frequencies of site-specific mutagenesis and gene targeting in Arabidopsis by manipulating DNA repair pathways

Improved methods for engineering sequence-specific nucleases, including zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs), have made it possible to precisely modify plant genomes. However, the success of genome modification is largely dependent on the intrinsic activity of the enginee...

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Veröffentlicht in:	Genome research 2013-03, Vol.23 (3), p.547-554
Hauptverfasser:	Qi, Yiping, Zhang, Yong, Zhang, Feng, Baller, Joshua A, Cleland, Spencer C, Ryu, Yungil, Starker, Colby G, Voytas, Daniel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis Arabidopsis - genetics Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism DNA End-Joining Repair DNA Ligases - genetics DNA Ligases - metabolism DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism Gene Expression Profiling Gene Targeting - methods Genetic Loci Genome, Plant Homologous Recombination Method Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mutagenesis, Site-Directed - methods Mutation Plants, Genetically Modified Zinc Fingers - genetics
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