The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans
Abstract Introduction Aspirin's effectiveness in reducing cardiovascular disease events is inadequate in some individuals, a phenomenon termed aspirin “resistance”. The hypothesis that combining low dose aspirin with eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) reduces platelet func...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2012-10, Vol.87 (4), p.143-151 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Block, Robert C Kakinami, Lisa Jonovich, Matthew Antonetti, Illena Lawrence, Peter Meednu, Nida CalderonArtero, Pedro Mousa, Shaker A Thomas Brenna, J Georas, Steve |
| description | Abstract Introduction Aspirin's effectiveness in reducing cardiovascular disease events is inadequate in some individuals, a phenomenon termed aspirin “resistance”. The hypothesis that combining low dose aspirin with eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) reduces platelet function in the acute setting has not been investigated. Patients and methods We conducted a clinical trial of EPA+DHA and aspirin ingestion in healthy adults. Fasting blood samples were drawn at baseline and 4 h after supplementation with EPA/DHA (3.4 g/d), aspirin (81 mg), and both. Platelet function was measured using the Platelet Function Analyzer-100 (PFA-100). Plasma lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), autotaxin, angiogenesis activators, and cytokines were measured. Results Platelet function decreased with the combination of aspirin+EPA/DHA ( p =0.03) but not with either alone ( p >0.05). EPA-LPC increased ( p =0.002). Discussion and conclusions Our results demonstrate that a potentially beneficial effect on platelet function occurred within 4 h after ingestion of low-dose aspirin and EPA+DHA in healthy adults. |
| doi_str_mv | 10.1016/j.plefa.2012.08.007 |
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The hypothesis that combining low dose aspirin with eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) reduces platelet function in the acute setting has not been investigated. Patients and methods We conducted a clinical trial of EPA+DHA and aspirin ingestion in healthy adults. Fasting blood samples were drawn at baseline and 4 h after supplementation with EPA/DHA (3.4 g/d), aspirin (81 mg), and both. Platelet function was measured using the Platelet Function Analyzer-100 (PFA-100). Plasma lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), autotaxin, angiogenesis activators, and cytokines were measured. Results Platelet function decreased with the combination of aspirin+EPA/DHA ( p =0.03) but not with either alone ( p >0.05). EPA-LPC increased ( p =0.002). Discussion and conclusions Our results demonstrate that a potentially beneficial effect on platelet function occurred within 4 h after ingestion of low-dose aspirin and EPA+DHA in healthy adults.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2012.08.007</identifier><identifier>PMID: 23017325</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>Acetylsalicylic acid ; Advanced Basic Science ; Aspirin ; Aspirin - administration & dosage ; Aspirin - pharmacology ; Blood Platelets - drug effects ; Docosahexaenoic acid ; Docosahexaenoic Acids - administration & dosage ; Docosahexaenoic Acids - pharmacology ; Drug Combinations ; Eicosapentaenoic acid ; Eicosapentaenoic Acid - administration & dosage ; Eicosapentaenoic Acid - pharmacology ; Endocrinology & Metabolism ; Humans ; Omega-3 fatty acids ; Platelet function ; Platelet function analyzer-100 ; Platelet Function Tests</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2012-10, Vol.87 (4), p.143-151</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><rights>2012 Elsevier Ltd. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4297-b368b316acdecccd3a290ffd4995e29605e40d360be2d05f5624eac44a19d9383</citedby><cites>FETCH-LOGICAL-c4297-b368b316acdecccd3a290ffd4995e29605e40d360be2d05f5624eac44a19d9383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.plefa.2012.08.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23017325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Block, Robert C</creatorcontrib><creatorcontrib>Kakinami, Lisa</creatorcontrib><creatorcontrib>Jonovich, Matthew</creatorcontrib><creatorcontrib>Antonetti, Illena</creatorcontrib><creatorcontrib>Lawrence, Peter</creatorcontrib><creatorcontrib>Meednu, Nida</creatorcontrib><creatorcontrib>CalderonArtero, Pedro</creatorcontrib><creatorcontrib>Mousa, Shaker A</creatorcontrib><creatorcontrib>Thomas Brenna, J</creatorcontrib><creatorcontrib>Georas, Steve</creatorcontrib><title>The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Abstract Introduction Aspirin's effectiveness in reducing cardiovascular disease events is inadequate in some individuals, a phenomenon termed aspirin “resistance”. The hypothesis that combining low dose aspirin with eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) reduces platelet function in the acute setting has not been investigated. Patients and methods We conducted a clinical trial of EPA+DHA and aspirin ingestion in healthy adults. Fasting blood samples were drawn at baseline and 4 h after supplementation with EPA/DHA (3.4 g/d), aspirin (81 mg), and both. Platelet function was measured using the Platelet Function Analyzer-100 (PFA-100). Plasma lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), autotaxin, angiogenesis activators, and cytokines were measured. Results Platelet function decreased with the combination of aspirin+EPA/DHA ( p =0.03) but not with either alone ( p >0.05). EPA-LPC increased ( p =0.002). Discussion and conclusions Our results demonstrate that a potentially beneficial effect on platelet function occurred within 4 h after ingestion of low-dose aspirin and EPA+DHA in healthy adults.</description><subject>Acetylsalicylic acid</subject><subject>Advanced Basic Science</subject><subject>Aspirin</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - pharmacology</subject><subject>Blood Platelets - drug effects</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - administration & dosage</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Drug Combinations</subject><subject>Eicosapentaenoic acid</subject><subject>Eicosapentaenoic Acid - administration & dosage</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Endocrinology & Metabolism</subject><subject>Humans</subject><subject>Omega-3 fatty acids</subject><subject>Platelet function</subject><subject>Platelet function analyzer-100</subject><subject>Platelet Function Tests</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUl1rFDEUHUSxa_UXCJJHQWbNx8zs5MHCUqsVCgrW53A3udPJmknWZKZl_oE_2-xuLeqLT4Hc83E55xbFS0aXjLLm7Xa5c9jBklPGl7RdUrp6VCxYLXjJWy4eFwsqa14KvmpPimcpbSmlnLHqaXHCBWUrwetF8fO6R6LDsLEeRhs8CR25-LJ-8_5yTcAb4sJdaUJCAmlno_XE-htMB2REM2lMZOdgRIcj6SavDxPQU_6ZyV2PESERBN0TcMEjGWAmPoxZhvQIbuxn0k8D-PS8eNKBS_ji_j0tvn24uD6_LK8-f_x0vr4qdcXlqtyIpt0I1oA2qLU2ArikXWcqKWvksqE1VtSIhm6QG1p3dcOrbF9VwKSRohWnxdlRdzdtBjQa_RjBqV20A8RZBbDq74m3vboJt0rUrWRCZoHX9wIx_JhyFmqwSaNz4DFMSbGceiM4402GiiNUx5BSxO7BhlG171Bt1aFDte9Q0VblDjPr1Z8bPnB-l5YB744AzDndWowqaYteo7ER9ahMsP8xOPuHr531VoP7jjOmbZiizxUoplLmqK_7M9pfEeOUskpW4he-tMX9</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Block, Robert C</creator><creator>Kakinami, Lisa</creator><creator>Jonovich, Matthew</creator><creator>Antonetti, Illena</creator><creator>Lawrence, Peter</creator><creator>Meednu, Nida</creator><creator>CalderonArtero, Pedro</creator><creator>Mousa, Shaker A</creator><creator>Thomas Brenna, J</creator><creator>Georas, Steve</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201210</creationdate><title>The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans</title><author>Block, Robert C ; Kakinami, Lisa ; Jonovich, Matthew ; Antonetti, Illena ; Lawrence, Peter ; Meednu, Nida ; CalderonArtero, Pedro ; Mousa, Shaker A ; Thomas Brenna, J ; Georas, Steve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4297-b368b316acdecccd3a290ffd4995e29605e40d360be2d05f5624eac44a19d9383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acetylsalicylic acid</topic><topic>Advanced Basic Science</topic><topic>Aspirin</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - pharmacology</topic><topic>Blood Platelets - drug effects</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - administration & dosage</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Drug Combinations</topic><topic>Eicosapentaenoic acid</topic><topic>Eicosapentaenoic Acid - administration & dosage</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Endocrinology & Metabolism</topic><topic>Humans</topic><topic>Omega-3 fatty acids</topic><topic>Platelet function</topic><topic>Platelet function analyzer-100</topic><topic>Platelet Function Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Block, Robert C</creatorcontrib><creatorcontrib>Kakinami, Lisa</creatorcontrib><creatorcontrib>Jonovich, Matthew</creatorcontrib><creatorcontrib>Antonetti, Illena</creatorcontrib><creatorcontrib>Lawrence, Peter</creatorcontrib><creatorcontrib>Meednu, Nida</creatorcontrib><creatorcontrib>CalderonArtero, Pedro</creatorcontrib><creatorcontrib>Mousa, Shaker A</creatorcontrib><creatorcontrib>Thomas Brenna, J</creatorcontrib><creatorcontrib>Georas, Steve</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Block, Robert C</au><au>Kakinami, Lisa</au><au>Jonovich, Matthew</au><au>Antonetti, Illena</au><au>Lawrence, Peter</au><au>Meednu, Nida</au><au>CalderonArtero, Pedro</au><au>Mousa, Shaker A</au><au>Thomas Brenna, J</au><au>Georas, Steve</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2012-10</date><risdate>2012</risdate><volume>87</volume><issue>4</issue><spage>143</spage><epage>151</epage><pages>143-151</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract Introduction Aspirin's effectiveness in reducing cardiovascular disease events is inadequate in some individuals, a phenomenon termed aspirin “resistance”. The hypothesis that combining low dose aspirin with eicosapentaenoic acid and docosahexaenoic acid (EPA+DHA) reduces platelet function in the acute setting has not been investigated. Patients and methods We conducted a clinical trial of EPA+DHA and aspirin ingestion in healthy adults. Fasting blood samples were drawn at baseline and 4 h after supplementation with EPA/DHA (3.4 g/d), aspirin (81 mg), and both. Platelet function was measured using the Platelet Function Analyzer-100 (PFA-100). Plasma lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), autotaxin, angiogenesis activators, and cytokines were measured. Results Platelet function decreased with the combination of aspirin+EPA/DHA ( p =0.03) but not with either alone ( p >0.05). EPA-LPC increased ( p =0.002). Discussion and conclusions Our results demonstrate that a potentially beneficial effect on platelet function occurred within 4 h after ingestion of low-dose aspirin and EPA+DHA in healthy adults.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>23017325</pmid><doi>10.1016/j.plefa.2012.08.007</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2012-10, Vol.87 (4), p.143-151 |
| issn | 0952-3278 1532-2823 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3589139 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetylsalicylic acid Advanced Basic Science Aspirin Aspirin - administration & dosage Aspirin - pharmacology Blood Platelets - drug effects Docosahexaenoic acid Docosahexaenoic Acids - administration & dosage Docosahexaenoic Acids - pharmacology Drug Combinations Eicosapentaenoic acid Eicosapentaenoic Acid - administration & dosage Eicosapentaenoic Acid - pharmacology Endocrinology & Metabolism Humans Omega-3 fatty acids Platelet function Platelet function analyzer-100 Platelet Function Tests |
| title | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans |
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