Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes

Acetate supplementation attenuates neuroglia activation in a rat model of neuroinflammation by a mechanism associated with an increase in brain acetyl-CoA, an alteration in histone acetylation, and reduction of interleukin (IL)-1β expression. We propose that reduced astroglial activation occurs by d...

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Veröffentlicht in:	Journal of neuroimmune pharmacology 2013-03, Vol.8 (1), p.287-300
Hauptverfasser:	Soliman, Mahmoud L., Combs, Colin K., Rosenberger, Thad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Acetyl Coenzyme A - metabolism Acetylation Animals Astrocytes - drug effects Astrocytes - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cell Biology Cells, Cultured Cytokines Cytokines - metabolism Histones - metabolism Immunology In Situ Nick-End Labeling Inflammation - metabolism Inflammation - pathology Kinases L-Lactate Dehydrogenase - metabolism Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - pharmacology MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Neurosciences NF-kappa B - metabolism Original Article Pharmacology/Toxicology Proteins Real-Time Polymerase Chain Reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics Rodents Signal Transduction - drug effects Signal Transduction - physiology Tumor necrosis factor-TNF Virology
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