Strain differences in the effects of chronic corticosterone exposure in the hippocampus
Highlights ► Strain differences in the effects of chronic CORT exposure in MRL and B6 mice. ► MRL mice are resistant to the effects of CORT on cell proliferation and BDNF levels. ► Strain differences are not dependent on blood or brain levels of glucocorticoids. ► MRL mice have higher expression of...
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| Veröffentlicht in: | Neuroscience 2012-10, Vol.222, p.269-280 |
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| creator | Hodes, G.E Brookshire, B.R Hill-Smith, T.E Teegarden, S.L Berton, O Lucki, I |
| description | Highlights ► Strain differences in the effects of chronic CORT exposure in MRL and B6 mice. ► MRL mice are resistant to the effects of CORT on cell proliferation and BDNF levels. ► Strain differences are not dependent on blood or brain levels of glucocorticoids. ► MRL mice have higher expression of NMDA receptor subtypes and MMPs than B6 mice. ► MRL mice are resistant to the effects of CORT on TrkB receptor expression. |
| doi_str_mv | 10.1016/j.neuroscience.2012.06.017 |
| format | Article |
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Psychology ; Gene Expression - drug effects ; Hippocampus - drug effects ; Male ; matrix metaloproteinases ; Mice ; Mice, Inbred C57BL ; Mice, Inbred MRL lpr ; neurogenesis ; Neurology ; neurotrophins ; NMDA receptor ; Real-Time Polymerase Chain Reaction ; Receptors, Glucocorticoid - biosynthesis ; Species Specificity ; strain differences ; stress ; Transcortin - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience, 2012-10, Vol.222, p.269-280</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012. 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Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Hippocampus - drug effects</subject><subject>Male</subject><subject>matrix metaloproteinases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred MRL lpr</subject><subject>neurogenesis</subject><subject>Neurology</subject><subject>neurotrophins</subject><subject>NMDA receptor</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptors, Glucocorticoid - biosynthesis</subject><subject>Species Specificity</subject><subject>strain differences</subject><subject>stress</subject><subject>Transcortin - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQtRCILoW_gCIkjgn-jLMcKqECLVIlDgVxtLzjMeslG0d2UrX_Hke7LYUTvlgz894b-80Q8obRhlHWvts1A84pZgg4ADacMt7QtqFMPyEr1mlRayXlU7Kigra1VJyfkBc572g5Sorn5IRzLZTSakV-XE_JhqFywXtMi16uSjhtscKSgSlX0VewTXEIUEFMU4CYJyxxQdyOMc8J7xnbMI4R7H6c80vyzNs-46vjfUq-f_707fyyvvp68eX8w1UNreimWlHtne5k6yx0a8Ek6A14DgAeQG18KWtKS0J1685xTVG0DiV3UjFU6404JWcH3XHe7NEBDuU_vRlT2Nt0Z6IN5u_KELbmZ7wxQnWaaVEE3h8EoDiaE_oHLqNmsdvszGO7zWK3oa0pdhfy68fdH6j3_hbA2yPAZrC9T3aAkP_gWkm1XHcF9_GAw-LVTcBkju1cSGUIxsXwf-85-0cG-lAGZ_tfeId5F-c0lGkYZnLhmOtlQZb9YJzSdnHjN3zNvZ4</recordid><startdate>20121011</startdate><enddate>20121011</enddate><creator>Hodes, G.E</creator><creator>Brookshire, B.R</creator><creator>Hill-Smith, T.E</creator><creator>Teegarden, S.L</creator><creator>Berton, O</creator><creator>Lucki, I</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20121011</creationdate><title>Strain differences in the effects of chronic corticosterone exposure in the hippocampus</title><author>Hodes, G.E ; Brookshire, B.R ; Hill-Smith, T.E ; Teegarden, S.L ; Berton, O ; Lucki, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c638t-507fd7846dac89314c7bcf2cccfcc5bf07f700f2c5898d270e36de42d451e59b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antidepressive Agents - pharmacology</topic><topic>BDNF</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cell Proliferation - drug effects</topic><topic>corticosterone</topic><topic>Corticosterone - administration & dosage</topic><topic>Corticosterone - metabolism</topic><topic>Corticosterone - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Implants</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression - drug effects</topic><topic>Hippocampus - drug effects</topic><topic>Male</topic><topic>matrix metaloproteinases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred MRL lpr</topic><topic>neurogenesis</topic><topic>Neurology</topic><topic>neurotrophins</topic><topic>NMDA receptor</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptors, Glucocorticoid - biosynthesis</topic><topic>Species Specificity</topic><topic>strain differences</topic><topic>stress</topic><topic>Transcortin - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hodes, G.E</creatorcontrib><creatorcontrib>Brookshire, B.R</creatorcontrib><creatorcontrib>Hill-Smith, T.E</creatorcontrib><creatorcontrib>Teegarden, S.L</creatorcontrib><creatorcontrib>Berton, O</creatorcontrib><creatorcontrib>Lucki, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hodes, G.E</au><au>Brookshire, B.R</au><au>Hill-Smith, T.E</au><au>Teegarden, S.L</au><au>Berton, O</au><au>Lucki, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Strain differences in the effects of chronic corticosterone exposure in the hippocampus</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2012-10-11</date><risdate>2012</risdate><volume>222</volume><spage>269</spage><epage>280</epage><pages>269-280</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Highlights ► Strain differences in the effects of chronic CORT exposure in MRL and B6 mice. ► MRL mice are resistant to the effects of CORT on cell proliferation and BDNF levels. ► Strain differences are not dependent on blood or brain levels of glucocorticoids. ► MRL mice have higher expression of NMDA receptor subtypes and MMPs than B6 mice. ► MRL mice are resistant to the effects of CORT on TrkB receptor expression.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>22735575</pmid><doi>10.1016/j.neuroscience.2012.06.017</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antidepressive Agents - pharmacology BDNF Behavior, Animal - drug effects Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism Cell Proliferation - drug effects corticosterone Corticosterone - administration & dosage Corticosterone - metabolism Corticosterone - toxicity Dose-Response Relationship, Drug Drug Implants Enzyme-Linked Immunosorbent Assay Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Hippocampus - drug effects Male matrix metaloproteinases Mice Mice, Inbred C57BL Mice, Inbred MRL lpr neurogenesis Neurology neurotrophins NMDA receptor Real-Time Polymerase Chain Reaction Receptors, Glucocorticoid - biosynthesis Species Specificity strain differences stress Transcortin - metabolism Vertebrates: nervous system and sense organs |
| title | Strain differences in the effects of chronic corticosterone exposure in the hippocampus |
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