Strain differences in the effects of chronic corticosterone exposure in the hippocampus

Highlights ► Strain differences in the effects of chronic CORT exposure in MRL and B6 mice. ► MRL mice are resistant to the effects of CORT on cell proliferation and BDNF levels. ► Strain differences are not dependent on blood or brain levels of glucocorticoids. ► MRL mice have higher expression of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2012-10, Vol.222, p.269-280
Hauptverfasser:	Hodes, G.E, Brookshire, B.R, Hill-Smith, T.E, Teegarden, S.L, Berton, O, Lucki, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology BDNF Behavior, Animal - drug effects Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism Cell Proliferation - drug effects corticosterone Corticosterone - administration & dosage Corticosterone - metabolism Corticosterone - toxicity Dose-Response Relationship, Drug Drug Implants Enzyme-Linked Immunosorbent Assay Flow Cytometry Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Hippocampus - drug effects Male matrix metaloproteinases Mice Mice, Inbred C57BL Mice, Inbred MRL lpr neurogenesis Neurology neurotrophins NMDA receptor Real-Time Polymerase Chain Reaction Receptors, Glucocorticoid - biosynthesis Species Specificity strain differences stress Transcortin - metabolism Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Strain differences in the effects of chronic CORT exposure in MRL and B6 mice. ► MRL mice are resistant to the effects of CORT on cell proliferation and BDNF levels. ► Strain differences are not dependent on blood or brain levels of glucocorticoids. ► MRL mice have higher expression of NMDA receptor subtypes and MMPs than B6 mice. ► MRL mice are resistant to the effects of CORT on TrkB receptor expression.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.06.017