MCP-induced protein 1 suppresses TNFα-induced VCAM-1 expression in human endothelial cells

Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor (TNF) α substantially increased...

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Veröffentlicht in:	FEBS letters 2010-07, Vol.584 (14), p.3065-3072
Hauptverfasser:	Qi, Yongfen, Liang, Jian, She, Zhi-Gang, Cai, Yan, Wang, Jing, Lei, Tianhua, Stallcup, William B., Fu, Mingui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion molecule Endothelial cell human umbilical vein endothelial cells HUVECs ICAM-1 IL-1β Inflammation intercellular adhesion molecule-1 interleukin 1β lipopolysaccharide LPS MCP-1 MCP-induced protein 1 MCPIP1 monocyte chemotactic protein 1 NF-κB NF-κB signaling nuclear factor-κB TNF tumor necrosis factor vascular cell adhesion molecule-1 VCAM-1
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