Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression
► First article describing senescence, metabolic and immune abnormalities in naïve patients with depression suggesting an accelerated aging state. Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. Ho...
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| Veröffentlicht in: | Brain, behavior, and immunity behavior, and immunity, 2013-02, Vol.28, p.49-53 |
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| creator | Garcia-Rizo, Clemente Fernandez-Egea, Emilio Miller, Brian J Oliveira, Cristina Justicia, Azucena Griffith, Jeffrey K Heaphy, Christopher M Bernardo, Miguel Kirkpatrick, Brian |
| description | ► First article describing senescence, metabolic and immune abnormalities in naïve patients with depression suggesting an accelerated aging state.
Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p |
| doi_str_mv | 10.1016/j.bbi.2012.11.009 |
| format | Article |
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Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p<.001); for lymphocyte count 2.1×109/L [0.6] vs 2.5×109/L [0.7] p=.028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p<0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease.</description><identifier>ISSN: 0889-1591</identifier><identifier>EISSN: 1090-2139</identifier><identifier>DOI: 10.1016/j.bbi.2012.11.009</identifier><identifier>PMID: 23207109</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Accelerated aging ; Adult ; Allergy and Immunology ; Blood Glucose - analysis ; Case-Control Studies ; Depressive Disorder, Major - immunology ; Depressive Disorder, Major - physiopathology ; Diabetes mellitus ; Drug-naïve ; Female ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Immunosenescence ; Interview, Psychological ; Leukocyte Count ; Lymphocyte Count ; Lymphopenia ; Major depressive disorder ; Male ; Psychiatric Status Rating Scales ; Psychiatry ; Telomere ; Telomere Shortening - physiology</subject><ispartof>Brain, behavior, and immunity, 2013-02, Vol.28, p.49-53</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><rights>2012 Elsevier Inc. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-dc065b5c5e5bbdb6f0d14f08923983073bfcdfe8ecd48da084a27c056fb26c433</citedby><cites>FETCH-LOGICAL-c539t-dc065b5c5e5bbdb6f0d14f08923983073bfcdfe8ecd48da084a27c056fb26c433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0889159112004953$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23207109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia-Rizo, Clemente</creatorcontrib><creatorcontrib>Fernandez-Egea, Emilio</creatorcontrib><creatorcontrib>Miller, Brian J</creatorcontrib><creatorcontrib>Oliveira, Cristina</creatorcontrib><creatorcontrib>Justicia, Azucena</creatorcontrib><creatorcontrib>Griffith, Jeffrey K</creatorcontrib><creatorcontrib>Heaphy, Christopher M</creatorcontrib><creatorcontrib>Bernardo, Miguel</creatorcontrib><creatorcontrib>Kirkpatrick, Brian</creatorcontrib><title>Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression</title><title>Brain, behavior, and immunity</title><addtitle>Brain Behav Immun</addtitle><description>► First article describing senescence, metabolic and immune abnormalities in naïve patients with depression suggesting an accelerated aging state.
Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p<.001); for lymphocyte count 2.1×109/L [0.6] vs 2.5×109/L [0.7] p=.028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p<0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease.</description><subject>Accelerated aging</subject><subject>Adult</subject><subject>Allergy and Immunology</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Depressive Disorder, Major - immunology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diabetes mellitus</subject><subject>Drug-naïve</subject><subject>Female</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Immunosenescence</subject><subject>Interview, Psychological</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Count</subject><subject>Lymphopenia</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Telomere</subject><subject>Telomere Shortening - physiology</subject><issn>0889-1591</issn><issn>1090-2139</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFuEzEQhlcIREPhAbggHzl0w9heZ3eFVKmqKCBV4gCcLa89mzg4drB3E-UV-jI8RF8MrxIq4IA42dJ8_6-Z-acoXlKYU6CLN-t519k5A8rmlM4B2kfFjEILJaO8fVzMoGnakoqWnhXPUloDgOC0eVqcMc6gzuSsuLvqfIgb5cjSjTokJENwGJXXeEH2Kzsg6VwIhmh0jugw-uGCKG_IgC5sMCJx6JfDilhPPO7dgRirlj4bmYkbrMFtxJTyt_Tq_scOyVYNFv2QyN5m3alug39ePOmVS_ji9J4XX2_efbn-UN5-ev_x-uq21IK3Q2k0LEQntEDRdaZb9GBo1UPTMt42HGre9dr02KA2VWMUNJVitQax6Du20BXn58Xl0Xc7dhs0OvcSlZPbaDcqHmRQVv5Z8XYll2EnuWhqyiaD1yeDGL6PmAa5sWnaj_IYxiQpq7kAWlfsf9AMN5WoMkqPqI4hpYj9Q0cU5BS3XMsct5zilpTKHHfWvPp9lAfFr3wz8PYIYF7ozmKUSeflazQ2oh6kCfaf9pd_qbWz3mrlvuEB0zqM0eekJJWJSZCfp3ubzo0ygKoVnP8Efv3Ueg</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Garcia-Rizo, Clemente</creator><creator>Fernandez-Egea, Emilio</creator><creator>Miller, Brian J</creator><creator>Oliveira, Cristina</creator><creator>Justicia, Azucena</creator><creator>Griffith, Jeffrey K</creator><creator>Heaphy, Christopher M</creator><creator>Bernardo, Miguel</creator><creator>Kirkpatrick, Brian</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130201</creationdate><title>Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression</title><author>Garcia-Rizo, Clemente ; Fernandez-Egea, Emilio ; Miller, Brian J ; Oliveira, Cristina ; Justicia, Azucena ; Griffith, Jeffrey K ; Heaphy, Christopher M ; Bernardo, Miguel ; Kirkpatrick, Brian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-dc065b5c5e5bbdb6f0d14f08923983073bfcdfe8ecd48da084a27c056fb26c433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accelerated aging</topic><topic>Adult</topic><topic>Allergy and Immunology</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Depressive Disorder, Major - immunology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diabetes mellitus</topic><topic>Drug-naïve</topic><topic>Female</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Immunosenescence</topic><topic>Interview, Psychological</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Count</topic><topic>Lymphopenia</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Telomere</topic><topic>Telomere Shortening - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia-Rizo, Clemente</creatorcontrib><creatorcontrib>Fernandez-Egea, Emilio</creatorcontrib><creatorcontrib>Miller, Brian J</creatorcontrib><creatorcontrib>Oliveira, Cristina</creatorcontrib><creatorcontrib>Justicia, Azucena</creatorcontrib><creatorcontrib>Griffith, Jeffrey K</creatorcontrib><creatorcontrib>Heaphy, Christopher M</creatorcontrib><creatorcontrib>Bernardo, Miguel</creatorcontrib><creatorcontrib>Kirkpatrick, Brian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain, behavior, and immunity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia-Rizo, Clemente</au><au>Fernandez-Egea, Emilio</au><au>Miller, Brian J</au><au>Oliveira, Cristina</au><au>Justicia, Azucena</au><au>Griffith, Jeffrey K</au><au>Heaphy, Christopher M</au><au>Bernardo, Miguel</au><au>Kirkpatrick, Brian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression</atitle><jtitle>Brain, behavior, and immunity</jtitle><addtitle>Brain Behav Immun</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>28</volume><spage>49</spage><epage>53</epage><pages>49-53</pages><issn>0889-1591</issn><eissn>1090-2139</eissn><abstract>► First article describing senescence, metabolic and immune abnormalities in naïve patients with depression suggesting an accelerated aging state.
Chronic mood disorders have been associated with a shortened telomere, a marker of increased mortality rate and aging, and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length to depression in newly diagnosed, antidepressant-naïve patients. Subjects with major depression (n=15), and matched healthy control subjects (n=70) underwent a two-hour oral glucose tolerance test and evaluation of blood cell count and telomere content. The depression group had significantly higher two-hour glucose concentrations and a lower lymphocyte count than control subjects (respective means [SD] for two-hour glucose were 125.0mg/dL [67.9] vs 84.6 [25.6] (p<.001); for lymphocyte count 2.1×109/L [0.6] vs 2.5×109/L [0.7] p=.028). Telomere content was significantly shortened in the depression group (87.9 [7.6]) compared to control subjects (101.0 [14.3]; p<0.01). Abnormal glucose tolerance, lymphopenia and a shortened telomere are present early in the course of depression independently of the confounding effect of antidepressant treatment, supporting the concept of major depression as an accelerated aging disease.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23207109</pmid><doi>10.1016/j.bbi.2012.11.009</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Brain, behavior, and immunity, 2013-02, Vol.28, p.49-53 |
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| subjects | Accelerated aging Adult Allergy and Immunology Blood Glucose - analysis Case-Control Studies Depressive Disorder, Major - immunology Depressive Disorder, Major - physiopathology Diabetes mellitus Drug-naïve Female Glucose tolerance Glucose Tolerance Test Humans Immunosenescence Interview, Psychological Leukocyte Count Lymphocyte Count Lymphopenia Major depressive disorder Male Psychiatric Status Rating Scales Psychiatry Telomere Telomere Shortening - physiology |
| title | Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression |
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