Src binds cortactin through an SH2 domain cystine-mediated linkage

Tyrosine-kinase-based signal transduction mediated by modular protein domains is critical for cellular function. The Src homology (SH)2 domain is an important conductor of intracellular signaling that binds to phosphorylated tyrosines on acceptor proteins, producing molecular complexes responsible f...

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Veröffentlicht in:	Journal of cell science 2012-12, Vol.125 (Pt 24), p.6185-6197
Hauptverfasser:	Evans, Jason V, Ammer, Amanda G, Jett, John E, Bolcato, Chris A, Breaux, Jason C, Martin, Karen H, Culp, Mark V, Gannett, Peter M, Weed, Scott A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Cell Line Cortactin - genetics Cortactin - metabolism Cystine - genetics Cystine - metabolism Humans Models, Molecular Molecular Sequence Data Phosphorylation Protein Binding Signal Transduction src Homology Domains src-Family Kinases - genetics src-Family Kinases - metabolism
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