The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde
The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes und...
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| Veröffentlicht in: | Nucleus (Austin, Tex.) Tex.), 2013-01, Vol.4 (1), p.37-42 |
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| creator | Bui, Minh Walkiewicz, Marcin P. Dimitriadis, Emilios K. Dalal, Yamini |
| description | The structure of the centromere-specific histone centromeric protein A (CENP-A) nucleosome has been a hot topic of debate for the past five years. Structures proposed include octamers, hexamers, homotypic and heterotypic tetramers. This controversy has led to the proposal that CENP-A nucleosomes undergo cell-cycle dependent transitions between the multiple states previously documented to exist in vivo and in vitro. In recent work from our laboratory, we sought to test this hypothesis. We discovered that CENP-A nucleosomes undergo unique oscillations in human cells, a finding mirrored in a parallel study performed in budding yeast. This review provides additional insights into the potential mechanisms for the interconversion of CENP-A nucleosomal species, and speculates on a biological role for oscillations in vivo. |
| doi_str_mv | 10.4161/nucl.23588 |
| format | Article |
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| source | Taylor & Francis Open Access; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | acetylation AFM Autoantigens - chemistry Autoantigens - metabolism Cell Cycle CENP-A Centromere Protein A Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - metabolism DNA-Binding Proteins - metabolism Extra View hemisome histones Histones - chemistry Histones - metabolism Humans nucleosome nucleosomes Nucleosomes - chemistry Nucleosomes - metabolism octamer oscillation Protein Multimerization structure tetramer yeasts |
| title | The CENP-A nucleosome: A battle between Dr Jekyll and Mr Hyde |
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