Established breast cancer stem cell markers do not correlate with in vivo tumorigenicity of tumor-initiating cells

The tumor-initiating capacity of primary human breast cancer cells is maintained in vitro by culturing these cells as spheres/aggregates. Inoculation of small cell numbers derived from these non-adherent cultures leads to rapid xenograft tumor formation in mice. Accordingly, injection of more differ...

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Veröffentlicht in:	International journal of oncology 2012-12, Vol.41 (6), p.1932-1942
Hauptverfasser:	LEHMANN, CHRISTIAN, JOBS, GABRIELE, THOMAS, MARKUS, BURTSCHER, HELMUT, KUBBIES, MANFRED
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer therapies Cell culture Cell Cycle Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Chemotherapy Cloning Cluster Analysis Dehydrogenases Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genotype & phenotype Gynecology. Andrology. Obstetrics Humans Immunophenotyping Mammary gland diseases mammospheres Medical sciences Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplastic Stem Cells - metabolism Physiology Population Spheres Spheroids, Cellular Stem cells Transcription factors Transplantation, Heterologous Tumor Cells, Cultured tumor initiating cells Tumors
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