Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway

Ophiopogonin B (OP-B) is a bioactive component of Radix Ophiopogon Japonicus, which is often used in Chinese traditional medicine to treat pulmonary disease. However, whether or not OP-B has any potential antitumor activity has not been reported. Here, we show that the non-small cell lung cancer (NS...

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Veröffentlicht in:	Oncology reports 2013-02, Vol.29 (2), p.430-436
Hauptverfasser:	CHEN, MEIJUAN, DU, YUHONG, QUI, MIN, WANG, MINGYAN, CHEN, KEJUN, HUANG, ZHENZHOU, JIANG, MIAO, XIONG, FEI, CHEN, JIANPING, ZHOU, JING, JIANG, FENGRONG, YIN, LIAN, TANG, YUPING, YE, LIHONG, ZHAN, ZHEN, DUAN, JIN-AO, FU, HAI-AN, ZHANG, XU
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Autophagy - drug effects Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - enzymology Cell cycle Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cytoplasm Humans Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - enzymology Microtubule-Associated Proteins - metabolism Morphology natural medicines non-small cell lung cancer Ophiopogonin B Phosphatidylinositol 3-Kinases - metabolism PI3K/Akt/mTOR Plant Extracts - pharmacology Proto-Oncogene Proteins c-akt - metabolism Saponins - pharmacology Signal Transduction - drug effects Spirostans - pharmacology Vacuoles - drug effects
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