Effect of sex steroids on Babesia microti infection in mice

Sex-based-differences are known to affect susceptibility to protozoan infections, but their effects on parasitemia and clinical symptoms in Babesia infections remain unclear. We examined the sex-based susceptibility of various mouse strains to Babesia microti Munich strain infection. In all strains,...

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Veröffentlicht in:	The American journal of tropical medicine and hygiene 2013-02, Vol.88 (2), p.367-375
Hauptverfasser:	Sasaki, Mizuki, Fujii, Yoshito, Iwamoto, Maya, Ikadai, Hiromi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology B-Lymphocytes - drug effects B-Lymphocytes - immunology Babesia Babesia microti Babesia microti - immunology Babesia microti - pathogenicity Babesiosis - immunology Babesiosis - parasitology Babesiosis - physiopathology Enzyme-Linked Immunosorbent Assay Estradiol - adverse effects Estradiol - therapeutic use Female Immunity, Innate Interferon-gamma - blood Male Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred ICR Real-Time Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, DNA T-Lymphocytes - drug effects T-Lymphocytes - immunology Testosterone - adverse effects Testosterone - immunology Tumor Necrosis Factor-alpha - blood
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