Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis
Objective To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. Design In vivo and vitro study. Setting University-based academic medical center. Patient(s) Reproductive-age women undergoing surgery for benign conditions. Inter...
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| Veröffentlicht in: | Fertility and sterility 2012-05, Vol.97 (5), p.1129-1135.e1 |
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| creator | Budrys, Nicole M., M.D., M.P.H Nair, Hareesh B., Ph.D Liu, Ya-Guang, Ph.D Kirma, Nameer B., Ph.D Binkley, Peter A., B.S Kumar, Shantha, Ph.D Schenken, Robert S., M.D Tekmal, Rajeshwar Rao, Ph.D |
| description | Objective To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. Design In vivo and vitro study. Setting University-based academic medical center. Patient(s) Reproductive-age women undergoing surgery for benign conditions. Intervention(s) Peritoneal and endometrial tissue samples were obtained. Main Outcome Measure(s) CSF-1 and C-FMS expression. Result(s) Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. Conclusion(s) Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling. |
| doi_str_mv | 10.1016/j.fertnstert.2012.02.007 |
| format | Article |
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Design In vivo and vitro study. Setting University-based academic medical center. Patient(s) Reproductive-age women undergoing surgery for benign conditions. Intervention(s) Peritoneal and endometrial tissue samples were obtained. Main Outcome Measure(s) CSF-1 and C-FMS expression. Result(s) Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. Conclusion(s) Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2012.02.007</identifier><identifier>PMID: 22365076</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Academic Medical Centers ; Ascitic Fluid - immunology ; Biological and medical sciences ; C-FMS ; Cell Communication ; cell culture ; Cells, Cultured ; coculture ; Coculture Techniques ; colony-stimulating factor 1 ; early lesion development ; Endometriosis ; Endometriosis - genetics ; Endometriosis - immunology ; Endometriosis - pathology ; endometrium ; Endometrium - immunology ; Endometrium - pathology ; epithelial cells ; Epithelial Cells - immunology ; Epithelial Cells - pathology ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Internal Medicine ; macrophage ; macrophage colony-stimulating factor ; Macrophage Colony-Stimulating Factor - genetics ; Macrophage Colony-Stimulating Factor - metabolism ; Medical sciences ; Non tumoral diseases ; Obstetrics and Gynecology ; patients ; peritoneal fluid ; Peritoneum - immunology ; Peritoneum - pathology ; Receptor, Macrophage Colony-Stimulating Factor - genetics ; Receptor, Macrophage Colony-Stimulating Factor - metabolism ; Stromal Cells - immunology ; Stromal Cells - pathology ; surgery ; Texas ; Up-Regulation ; women</subject><ispartof>Fertility and sterility, 2012-05, Vol.97 (5), p.1129-1135.e1</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2012 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright ©2012 American Society for Reproductive Medicine, Published by Elsevier Inc. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c588t-3e253d6d5f40b5fd1a416d9c8553f2c3b908765fb82b8ef3719ad300485b12bc3</citedby><cites>FETCH-LOGICAL-c588t-3e253d6d5f40b5fd1a416d9c8553f2c3b908765fb82b8ef3719ad300485b12bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S001502821200221X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25863361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22365076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Budrys, Nicole M., M.D., M.P.H</creatorcontrib><creatorcontrib>Nair, Hareesh B., Ph.D</creatorcontrib><creatorcontrib>Liu, Ya-Guang, Ph.D</creatorcontrib><creatorcontrib>Kirma, Nameer B., Ph.D</creatorcontrib><creatorcontrib>Binkley, Peter A., B.S</creatorcontrib><creatorcontrib>Kumar, Shantha, Ph.D</creatorcontrib><creatorcontrib>Schenken, Robert S., M.D</creatorcontrib><creatorcontrib>Tekmal, Rajeshwar Rao, Ph.D</creatorcontrib><title>Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. Design In vivo and vitro study. Setting University-based academic medical center. Patient(s) Reproductive-age women undergoing surgery for benign conditions. Intervention(s) Peritoneal and endometrial tissue samples were obtained. Main Outcome Measure(s) CSF-1 and C-FMS expression. Result(s) Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. Conclusion(s) Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling.</description><subject>Academic Medical Centers</subject><subject>Ascitic Fluid - immunology</subject><subject>Biological and medical sciences</subject><subject>C-FMS</subject><subject>Cell Communication</subject><subject>cell culture</subject><subject>Cells, Cultured</subject><subject>coculture</subject><subject>Coculture Techniques</subject><subject>colony-stimulating factor 1</subject><subject>early lesion development</subject><subject>Endometriosis</subject><subject>Endometriosis - genetics</subject><subject>Endometriosis - immunology</subject><subject>Endometriosis - pathology</subject><subject>endometrium</subject><subject>Endometrium - immunology</subject><subject>Endometrium - pathology</subject><subject>epithelial cells</subject><subject>Epithelial Cells - immunology</subject><subject>Epithelial Cells - pathology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>macrophage</subject><subject>macrophage colony-stimulating factor</subject><subject>Macrophage Colony-Stimulating Factor - genetics</subject><subject>Macrophage Colony-Stimulating Factor - metabolism</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Obstetrics and Gynecology</subject><subject>patients</subject><subject>peritoneal fluid</subject><subject>Peritoneum - immunology</subject><subject>Peritoneum - pathology</subject><subject>Receptor, Macrophage Colony-Stimulating Factor - genetics</subject><subject>Receptor, Macrophage Colony-Stimulating Factor - metabolism</subject><subject>Stromal Cells - immunology</subject><subject>Stromal Cells - pathology</subject><subject>surgery</subject><subject>Texas</subject><subject>Up-Regulation</subject><subject>women</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9uEzEQxlcIREPhFWAvSFwSxnbsdS6VoOJPpUocSiVultc7Thx27cV2CrnxDrwhT4JXCS1wQrJsafybmU_zTVXVBBYEiHi5XViM2adc7gUFQhdQDjT3qhnhXMy54Ox-NQMgfA5U0pPqUUpbABCkoQ-rE0qZ4NCIWeUvvImoE3Y1fhsjpuSCr4OtB21iGDd6jbUJffD7n99_pOyGXa-z8-vaapNDrLXvapdTHdHgOAWcr8dCoC_Bry5vavRdGDBHF5JLj6sHVvcJnxzf0-r67ZuP5-_nlx_eXZy_upwbLmWeM6ScdaLjdgkttx3RSyK6lZGcM0sNa1cgG8FtK2kr0bKGrHTHAJaSt4S2hp1WZ4e6464dsDNFTtS9GqMbdNyroJ36-8e7jVqHG8W4ZJRBKfDiWCCGLztMWQ0uGex77THskio2TN0EkILKA1oGllJEe9uGwMQJtVV3dqnJLgXlQFNSn_4p8zbxtz8FeH4EdDK6t1F749Idx6VgTEwanh04q4PS61iY66vSiZcVoHIJq0K8PhBYxn7jMKpkiksGO1e8y6oL7n_0nv1TxPTOu6LsM-4xbcMu-mKrIiqVBHU1LeC0f4QCUEo-sV8Eztuk</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Budrys, Nicole M., M.D., M.P.H</creator><creator>Nair, Hareesh B., Ph.D</creator><creator>Liu, Ya-Guang, Ph.D</creator><creator>Kirma, Nameer B., Ph.D</creator><creator>Binkley, Peter A., B.S</creator><creator>Kumar, Shantha, Ph.D</creator><creator>Schenken, Robert S., M.D</creator><creator>Tekmal, Rajeshwar Rao, Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120501</creationdate><title>Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis</title><author>Budrys, Nicole M., M.D., M.P.H ; Nair, Hareesh B., Ph.D ; Liu, Ya-Guang, Ph.D ; Kirma, Nameer B., Ph.D ; Binkley, Peter A., B.S ; Kumar, Shantha, Ph.D ; Schenken, Robert S., M.D ; Tekmal, Rajeshwar Rao, Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c588t-3e253d6d5f40b5fd1a416d9c8553f2c3b908765fb82b8ef3719ad300485b12bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Academic Medical Centers</topic><topic>Ascitic Fluid - immunology</topic><topic>Biological and medical sciences</topic><topic>C-FMS</topic><topic>Cell Communication</topic><topic>cell culture</topic><topic>Cells, Cultured</topic><topic>coculture</topic><topic>Coculture Techniques</topic><topic>colony-stimulating factor 1</topic><topic>early lesion development</topic><topic>Endometriosis</topic><topic>Endometriosis - genetics</topic><topic>Endometriosis - immunology</topic><topic>Endometriosis - pathology</topic><topic>endometrium</topic><topic>Endometrium - immunology</topic><topic>Endometrium - pathology</topic><topic>epithelial cells</topic><topic>Epithelial Cells - immunology</topic><topic>Epithelial Cells - pathology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>macrophage</topic><topic>macrophage colony-stimulating factor</topic><topic>Macrophage Colony-Stimulating Factor - genetics</topic><topic>Macrophage Colony-Stimulating Factor - metabolism</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Obstetrics and Gynecology</topic><topic>patients</topic><topic>peritoneal fluid</topic><topic>Peritoneum - immunology</topic><topic>Peritoneum - pathology</topic><topic>Receptor, Macrophage Colony-Stimulating Factor - genetics</topic><topic>Receptor, Macrophage Colony-Stimulating Factor - metabolism</topic><topic>Stromal Cells - immunology</topic><topic>Stromal Cells - pathology</topic><topic>surgery</topic><topic>Texas</topic><topic>Up-Regulation</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Budrys, Nicole M., M.D., M.P.H</creatorcontrib><creatorcontrib>Nair, Hareesh B., Ph.D</creatorcontrib><creatorcontrib>Liu, Ya-Guang, Ph.D</creatorcontrib><creatorcontrib>Kirma, Nameer B., Ph.D</creatorcontrib><creatorcontrib>Binkley, Peter A., B.S</creatorcontrib><creatorcontrib>Kumar, Shantha, Ph.D</creatorcontrib><creatorcontrib>Schenken, Robert S., M.D</creatorcontrib><creatorcontrib>Tekmal, Rajeshwar Rao, Ph.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Budrys, Nicole M., M.D., M.P.H</au><au>Nair, Hareesh B., Ph.D</au><au>Liu, Ya-Guang, Ph.D</au><au>Kirma, Nameer B., Ph.D</au><au>Binkley, Peter A., B.S</au><au>Kumar, Shantha, Ph.D</au><au>Schenken, Robert S., M.D</au><au>Tekmal, Rajeshwar Rao, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>97</volume><issue>5</issue><spage>1129</spage><epage>1135.e1</epage><pages>1129-1135.e1</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To investigate the expression and regulation of colony-stimulating factor 1 (CSF-1) and its receptor, C-FMS, in endometriosis. Design In vivo and vitro study. Setting University-based academic medical center. Patient(s) Reproductive-age women undergoing surgery for benign conditions. Intervention(s) Peritoneal and endometrial tissue samples were obtained. Main Outcome Measure(s) CSF-1 and C-FMS expression. Result(s) Significantly higher CSF-1 levels were found in peritoneal fluid of patients with endometriosis compared with control subjects. Ectopic endometriotic tissue had 3.5-fold and 1.7-fold increases in CSF-1 and C-FMS expression, respectively, compared with eutopic tissue. Coculture of endometrial cells from either established cell lines or patient samples with peritoneal mesothelial cells (PMCs) led to increased expression of CSF-1 and C-FMS. A higher but nonsignificant increase in levels of C-FMS and CSF-1 was found in cocultures of endometrial epithelial cells from patients with endometriosis compared with those without endometriosis. Conclusion(s) Increased CSF-1 levels may contribute to endometriosis lesion formation and progression. Elevation in CSF-1 after coculture of endometrial cells with PMCs suggests that endometrial tissue may be a source of peritoneal CSF-1. Increased C-FMS expression in endometrial cells from women with endometriosis cocultured with PMCs suggests that endometrial tissue involved in lesion formation is highly responsive to CSF-1 signaling.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22365076</pmid><doi>10.1016/j.fertnstert.2012.02.007</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Academic Medical Centers Ascitic Fluid - immunology Biological and medical sciences C-FMS Cell Communication cell culture Cells, Cultured coculture Coculture Techniques colony-stimulating factor 1 early lesion development Endometriosis Endometriosis - genetics Endometriosis - immunology Endometriosis - pathology endometrium Endometrium - immunology Endometrium - pathology epithelial cells Epithelial Cells - immunology Epithelial Cells - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Internal Medicine macrophage macrophage colony-stimulating factor Macrophage Colony-Stimulating Factor - genetics Macrophage Colony-Stimulating Factor - metabolism Medical sciences Non tumoral diseases Obstetrics and Gynecology patients peritoneal fluid Peritoneum - immunology Peritoneum - pathology Receptor, Macrophage Colony-Stimulating Factor - genetics Receptor, Macrophage Colony-Stimulating Factor - metabolism Stromal Cells - immunology Stromal Cells - pathology surgery Texas Up-Regulation women |
| title | Increased expression of macrophage colony–stimulating factor and its receptor in patients with endometriosis |
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