Ceramide‐1‐Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells—Implications for Tissue Regeneration
Ceramide‐1‐phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and “leaky.” As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue d...
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| Veröffentlicht in: | Stem cells (Dayton, Ohio) Ohio), 2013-03, Vol.31 (3), p.500-510 |
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| creator | Kim, Chihwa Schneider, Gabriela Abdel‐Latif, Ahmed Mierzejewska, Kasia Sunkara, Manjula Borkowska, Sylwia Ratajczak, Janina Morris, Andrew J. Kucia, Magda Ratajczak, Mariusz Z. |
| description | Ceramide‐1‐phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and “leaky.” As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for the first time that C1P is upregulated in damaged tissues and chemoattracts bone marrow (BM)‐derived multipotent stromal cells, endothelial progenitor cells, and very small embryonic‐like stem cells. Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal cell‐derived factor‐1 from BM‐derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization. STEM CELLS2013;31:500–510 |
| doi_str_mv | 10.1002/stem.1291 |
| format | Article |
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In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for the first time that C1P is upregulated in damaged tissues and chemoattracts bone marrow (BM)‐derived multipotent stromal cells, endothelial progenitor cells, and very small embryonic‐like stem cells. Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal cell‐derived factor‐1 from BM‐derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization. STEM CELLS2013;31:500–510</description><identifier>ISSN: 1066-5099</identifier><identifier>EISSN: 1549-4918</identifier><identifier>DOI: 10.1002/stem.1291</identifier><identifier>PMID: 23193025</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Angiogenesis ; Animals ; Bone marrow ; Cell Growth Processes - physiology ; Cell Movement - physiology ; Ceramides - biosynthesis ; Ceramides - metabolism ; Ceramide‐1‐phosphate ; Chemotactic Factors - biosynthesis ; Chemotactic Factors - metabolism ; Chemotaxis ; Human umbilical vein endothelial cell ; Human Umbilical Vein Endothelial Cells - cytology ; Human Umbilical Vein Endothelial Cells - metabolism ; Humans ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mice ; Mice, Inbred C57BL ; Multipotent stromal cell ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - pathology ; Regeneration - physiology ; Regenerative Medicine - methods ; Stem cells ; Stem Cells - cytology ; Stem Cells - metabolism ; Up-Regulation</subject><ispartof>Stem cells (Dayton, Ohio), 2013-03, Vol.31 (3), p.500-510</ispartof><rights>Copyright © 2012 AlphaMed Press</rights><rights>Copyright © 2012 AlphaMed Press.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5421-486286289691566c2175d2ab4a5614a451ec3e0209cb911340a731094ac8b66d3</citedby><cites>FETCH-LOGICAL-c5421-486286289691566c2175d2ab4a5614a451ec3e0209cb911340a731094ac8b66d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23193025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Chihwa</creatorcontrib><creatorcontrib>Schneider, Gabriela</creatorcontrib><creatorcontrib>Abdel‐Latif, Ahmed</creatorcontrib><creatorcontrib>Mierzejewska, Kasia</creatorcontrib><creatorcontrib>Sunkara, Manjula</creatorcontrib><creatorcontrib>Borkowska, Sylwia</creatorcontrib><creatorcontrib>Ratajczak, Janina</creatorcontrib><creatorcontrib>Morris, Andrew J.</creatorcontrib><creatorcontrib>Kucia, Magda</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><title>Ceramide‐1‐Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells—Implications for Tissue Regeneration</title><title>Stem cells (Dayton, Ohio)</title><addtitle>Stem Cells</addtitle><description>Ceramide‐1‐phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and “leaky.” As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for the first time that C1P is upregulated in damaged tissues and chemoattracts bone marrow (BM)‐derived multipotent stromal cells, endothelial progenitor cells, and very small embryonic‐like stem cells. Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal cell‐derived factor‐1 from BM‐derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization. STEM CELLS2013;31:500–510</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Bone marrow</subject><subject>Cell Growth Processes - physiology</subject><subject>Cell Movement - physiology</subject><subject>Ceramides - biosynthesis</subject><subject>Ceramides - metabolism</subject><subject>Ceramide‐1‐phosphate</subject><subject>Chemotactic Factors - biosynthesis</subject><subject>Chemotactic Factors - metabolism</subject><subject>Chemotaxis</subject><subject>Human umbilical vein endothelial cell</subject><subject>Human Umbilical Vein Endothelial Cells - cytology</subject><subject>Human Umbilical Vein Endothelial Cells - metabolism</subject><subject>Humans</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Multipotent stromal cell</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardial Ischemia - pathology</subject><subject>Regeneration - physiology</subject><subject>Regenerative Medicine - methods</subject><subject>Stem cells</subject><subject>Stem Cells - cytology</subject><subject>Stem Cells - metabolism</subject><subject>Up-Regulation</subject><issn>1066-5099</issn><issn>1549-4918</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFktFqFDEUhoMotl298AVkwBt7MW1OJskmN0JZVi10sdj1OmRnsrspmcmYZJTe9REUfMI-idmdWlQQISGHnI__5A8_Qi8AnwDG5DQm054AkfAIHQKjsqQSxONcY85LhqU8QEcxXmMMlAnxFB2QCmSFCTtE32cm6NY25u72G-R9ufWx3-pkio9mM7hcxGJhN0En67vCr4vF4JLtfTJdKq5S8K12xcw4FwvdNcW8a3zaGmfz7WXwG9PZ5MMI3N3-OG97Z-u9VizWubG0MQ77WaYz45Bn6Mlau2ie358T9OntfDl7X158eHc-O7soa0YJlFRwsluSS2Cc1wSmrCF6RTXjQDVlYOrKYIJlvZIAFcV6WgGWVNdixXlTTdCbUbcfVq1p6mwoaKf6YFsdbpTXVv3Z6exWbfwXVTFBBJVZ4PW9QPCfBxOTam2ss1PdGT9EBTQPJWIq8P_RCrIklqTK6Ku_0Gs_hC7_xI6aUi5IxiboeKTq4GMMZv3wbsBqlwm1y4TaZSKzL383-kD-CkEGTkfgq3Xm5t9K6mo5X-wlfwJfHMWf</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Kim, Chihwa</creator><creator>Schneider, Gabriela</creator><creator>Abdel‐Latif, Ahmed</creator><creator>Mierzejewska, Kasia</creator><creator>Sunkara, Manjula</creator><creator>Borkowska, Sylwia</creator><creator>Ratajczak, Janina</creator><creator>Morris, Andrew J.</creator><creator>Kucia, Magda</creator><creator>Ratajczak, Mariusz Z.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201303</creationdate><title>Ceramide‐1‐Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells—Implications for Tissue Regeneration</title><author>Kim, Chihwa ; Schneider, Gabriela ; Abdel‐Latif, Ahmed ; Mierzejewska, Kasia ; Sunkara, Manjula ; Borkowska, Sylwia ; Ratajczak, Janina ; Morris, Andrew J. ; Kucia, Magda ; Ratajczak, Mariusz Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5421-486286289691566c2175d2ab4a5614a451ec3e0209cb911340a731094ac8b66d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Bone marrow</topic><topic>Cell Growth Processes - physiology</topic><topic>Cell Movement - physiology</topic><topic>Ceramides - biosynthesis</topic><topic>Ceramides - metabolism</topic><topic>Ceramide‐1‐phosphate</topic><topic>Chemotactic Factors - biosynthesis</topic><topic>Chemotactic Factors - metabolism</topic><topic>Chemotaxis</topic><topic>Human umbilical vein endothelial cell</topic><topic>Human Umbilical Vein Endothelial Cells - cytology</topic><topic>Human Umbilical Vein Endothelial Cells - metabolism</topic><topic>Humans</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Multipotent stromal cell</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardial Ischemia - pathology</topic><topic>Regeneration - physiology</topic><topic>Regenerative Medicine - methods</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><topic>Stem Cells - metabolism</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Chihwa</creatorcontrib><creatorcontrib>Schneider, Gabriela</creatorcontrib><creatorcontrib>Abdel‐Latif, Ahmed</creatorcontrib><creatorcontrib>Mierzejewska, Kasia</creatorcontrib><creatorcontrib>Sunkara, Manjula</creatorcontrib><creatorcontrib>Borkowska, Sylwia</creatorcontrib><creatorcontrib>Ratajczak, Janina</creatorcontrib><creatorcontrib>Morris, Andrew J.</creatorcontrib><creatorcontrib>Kucia, Magda</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cells (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Chihwa</au><au>Schneider, Gabriela</au><au>Abdel‐Latif, Ahmed</au><au>Mierzejewska, Kasia</au><au>Sunkara, Manjula</au><au>Borkowska, Sylwia</au><au>Ratajczak, Janina</au><au>Morris, Andrew J.</au><au>Kucia, Magda</au><au>Ratajczak, Mariusz Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ceramide‐1‐Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells—Implications for Tissue Regeneration</atitle><jtitle>Stem cells (Dayton, Ohio)</jtitle><addtitle>Stem Cells</addtitle><date>2013-03</date><risdate>2013</risdate><volume>31</volume><issue>3</issue><spage>500</spage><epage>510</epage><pages>500-510</pages><issn>1066-5099</issn><eissn>1549-4918</eissn><abstract>Ceramide‐1‐phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and “leaky.” As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for the first time that C1P is upregulated in damaged tissues and chemoattracts bone marrow (BM)‐derived multipotent stromal cells, endothelial progenitor cells, and very small embryonic‐like stem cells. Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal cell‐derived factor‐1 from BM‐derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization. STEM CELLS2013;31:500–510</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23193025</pmid><doi>10.1002/stem.1291</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angiogenesis Animals Bone marrow Cell Growth Processes - physiology Cell Movement - physiology Ceramides - biosynthesis Ceramides - metabolism Ceramide‐1‐phosphate Chemotactic Factors - biosynthesis Chemotactic Factors - metabolism Chemotaxis Human umbilical vein endothelial cell Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - metabolism Humans Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice Mice, Inbred C57BL Multipotent stromal cell Myocardial Ischemia - metabolism Myocardial Ischemia - pathology Regeneration - physiology Regenerative Medicine - methods Stem cells Stem Cells - cytology Stem Cells - metabolism Up-Regulation |
| title | Ceramide‐1‐Phosphate Regulates Migration of Multipotent Stromal Cells and Endothelial Progenitor Cells—Implications for Tissue Regeneration |
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