Drug use and upper gastrointestinal complications in children: a case–control study
Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emerg...
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| Veröffentlicht in: | Archives of disease in childhood 2013-03, Vol.98 (3), p.218-221 |
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| creator | Bianciotto, Manuela Chiappini, Elena Raffaldi, Irene Gabiano, Clara Tovo, Pier-Angelo Sollai, Sara de Martino, Maurizio Mannelli, Francesco Tipo, Vincenzo Da Cas, Roberto Traversa, Giuseppe Menniti-Ippolito, Francesca |
| description | Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p |
| doi_str_mv | 10.1136/archdischild-2012-302100 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3582087</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4214850761</sourcerecordid><originalsourceid>FETCH-LOGICAL-b593t-c8ef19508a22855b4c08eaaf9b1c8f7a82b6e77fbf536a8b8ed25d49366a17a83</originalsourceid><addsrcrecordid>eNqNkU2O1DAQhS0EYpqBKyBLCIlNwD-x47BAguZfA2xmRuysiuN0u0nsYCeI2XGHueGcBDfdNAMrVpaqvnqueg8hTMljSrl8AtGsW5fM2vVtwQhlBSeMEnIDLWgpVS6V5U20IITwolZKHaE7KW1IBpXit9ER40yWJWcLdPYyzis8J4vBt3geRxvxCtIUg_OTTZPz0GMThrF3BiYXfMLO418fR-ufYsAGkr36cWmCz0M9TtPcXtxFtzrok723f4_R2etXp8u3xcmnN--Wz0-KRtR8KoyyHa0FUcCYEqIpDVEWoKsbalRXgWKNtFXVNZ3gElSjbMtEW9ZcSqC5zY_Rs53uODeDbY3NO0Cvx-gGiBc6gNN_d7xb61X4prlQjKgqCzzaC8Twdc736iHbavsevA1z0lQIKhmvBM_og3_QTZhjtidTKvuqsrk0U2pHmRhSirY7LEOJ3manr2ent9npXXZ59P71Yw6Dv8PKwMM9AMlA30XwxqU_nKyZoGwrVOw4lyb7_dCH-EXLKt-iP54vtfhQfj6l71_o88zzHd8Mm_9f9ycvq8g2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1828881281</pqid></control><display><type>article</type><title>Drug use and upper gastrointestinal complications in children: a case–control study</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Bianciotto, Manuela ; Chiappini, Elena ; Raffaldi, Irene ; Gabiano, Clara ; Tovo, Pier-Angelo ; Sollai, Sara ; de Martino, Maurizio ; Mannelli, Francesco ; Tipo, Vincenzo ; Da Cas, Roberto ; Traversa, Giuseppe ; Menniti-Ippolito, Francesca</creator><creatorcontrib>Bianciotto, Manuela ; Chiappini, Elena ; Raffaldi, Irene ; Gabiano, Clara ; Tovo, Pier-Angelo ; Sollai, Sara ; de Martino, Maurizio ; Mannelli, Francesco ; Tipo, Vincenzo ; Da Cas, Roberto ; Traversa, Giuseppe ; Menniti-Ippolito, Francesca ; Italian Multicenter Study Group for Drug and Vaccine Safety in Children ; and the Italian Multicenter Study Group for Drug and Vaccine Safety in Children</creatorcontrib><description>Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1–8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. Conclusions NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.</description><identifier>ISSN: 0003-9888</identifier><identifier>EISSN: 1468-2044</identifier><identifier>DOI: 10.1136/archdischild-2012-302100</identifier><identifier>PMID: 23264432</identifier><identifier>CODEN: ADCHAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Acetaminophen - adverse effects ; Addictive behaviors ; Adrenal Cortex Hormones - adverse effects ; Adult and adolescent clinical studies ; adverse events ; Anti-Bacterial Agents - adverse effects ; Anti-inflammatory agents ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Antibiotics ; Asthma ; Biological and medical sciences ; Case-Control Studies ; case-control study ; Child ; Child, Preschool ; Chronic illnesses ; Control Groups ; Data Analysis ; Drug addiction ; Drug Therapy ; Drug use ; Endoscopy ; Ethics ; Female ; gastrointestinal complications ; Gastrointestinal diseases ; Gastrointestinal Diseases - chemically induced ; General aspects ; Hospitalization ; Hospitals ; Humans ; Infant ; Italy - epidemiology ; Logistic Models ; Male ; Medical sciences ; Miscellaneous ; Narcotics ; Neurological disorders ; Nonsteroidal anti-inflammatory drugs ; Parents ; Pediatrics ; Prevention and actions ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk ; Statistical Analysis ; Steroids ; Surveillance ; Toxicity ; Upper Gastrointestinal Tract - pathology ; Vaccines</subject><ispartof>Archives of disease in childhood, 2013-03, Vol.98 (3), p.218-221</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b593t-c8ef19508a22855b4c08eaaf9b1c8f7a82b6e77fbf536a8b8ed25d49366a17a83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://adc.bmj.com/content/98/3/218.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://adc.bmj.com/content/98/3/218.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,777,781,882,3183,23552,27905,27906,77349,77380</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26925120$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23264432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bianciotto, Manuela</creatorcontrib><creatorcontrib>Chiappini, Elena</creatorcontrib><creatorcontrib>Raffaldi, Irene</creatorcontrib><creatorcontrib>Gabiano, Clara</creatorcontrib><creatorcontrib>Tovo, Pier-Angelo</creatorcontrib><creatorcontrib>Sollai, Sara</creatorcontrib><creatorcontrib>de Martino, Maurizio</creatorcontrib><creatorcontrib>Mannelli, Francesco</creatorcontrib><creatorcontrib>Tipo, Vincenzo</creatorcontrib><creatorcontrib>Da Cas, Roberto</creatorcontrib><creatorcontrib>Traversa, Giuseppe</creatorcontrib><creatorcontrib>Menniti-Ippolito, Francesca</creatorcontrib><creatorcontrib>Italian Multicenter Study Group for Drug and Vaccine Safety in Children</creatorcontrib><creatorcontrib>and the Italian Multicenter Study Group for Drug and Vaccine Safety in Children</creatorcontrib><title>Drug use and upper gastrointestinal complications in children: a case–control study</title><title>Archives of disease in childhood</title><addtitle>Arch Dis Child</addtitle><description>Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1–8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. Conclusions NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.</description><subject>Acetaminophen - adverse effects</subject><subject>Addictive behaviors</subject><subject>Adrenal Cortex Hormones - adverse effects</subject><subject>Adult and adolescent clinical studies</subject><subject>adverse events</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Antibiotics</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>case-control study</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic illnesses</subject><subject>Control Groups</subject><subject>Data Analysis</subject><subject>Drug addiction</subject><subject>Drug Therapy</subject><subject>Drug use</subject><subject>Endoscopy</subject><subject>Ethics</subject><subject>Female</subject><subject>gastrointestinal complications</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - chemically induced</subject><subject>General aspects</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Italy - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Narcotics</subject><subject>Neurological disorders</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Parents</subject><subject>Pediatrics</subject><subject>Prevention and actions</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk</subject><subject>Statistical Analysis</subject><subject>Steroids</subject><subject>Surveillance</subject><subject>Toxicity</subject><subject>Upper Gastrointestinal Tract - pathology</subject><subject>Vaccines</subject><issn>0003-9888</issn><issn>1468-2044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU2O1DAQhS0EYpqBKyBLCIlNwD-x47BAguZfA2xmRuysiuN0u0nsYCeI2XGHueGcBDfdNAMrVpaqvnqueg8hTMljSrl8AtGsW5fM2vVtwQhlBSeMEnIDLWgpVS6V5U20IITwolZKHaE7KW1IBpXit9ER40yWJWcLdPYyzis8J4vBt3geRxvxCtIUg_OTTZPz0GMThrF3BiYXfMLO418fR-ufYsAGkr36cWmCz0M9TtPcXtxFtzrok723f4_R2etXp8u3xcmnN--Wz0-KRtR8KoyyHa0FUcCYEqIpDVEWoKsbalRXgWKNtFXVNZ3gElSjbMtEW9ZcSqC5zY_Rs53uODeDbY3NO0Cvx-gGiBc6gNN_d7xb61X4prlQjKgqCzzaC8Twdc736iHbavsevA1z0lQIKhmvBM_og3_QTZhjtidTKvuqsrk0U2pHmRhSirY7LEOJ3manr2ent9npXXZ59P71Yw6Dv8PKwMM9AMlA30XwxqU_nKyZoGwrVOw4lyb7_dCH-EXLKt-iP54vtfhQfj6l71_o88zzHd8Mm_9f9ycvq8g2</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Bianciotto, Manuela</creator><creator>Chiappini, Elena</creator><creator>Raffaldi, Irene</creator><creator>Gabiano, Clara</creator><creator>Tovo, Pier-Angelo</creator><creator>Sollai, Sara</creator><creator>de Martino, Maurizio</creator><creator>Mannelli, Francesco</creator><creator>Tipo, Vincenzo</creator><creator>Da Cas, Roberto</creator><creator>Traversa, Giuseppe</creator><creator>Menniti-Ippolito, Francesca</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8A4</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20130301</creationdate><title>Drug use and upper gastrointestinal complications in children: a case–control study</title><author>Bianciotto, Manuela ; Chiappini, Elena ; Raffaldi, Irene ; Gabiano, Clara ; Tovo, Pier-Angelo ; Sollai, Sara ; de Martino, Maurizio ; Mannelli, Francesco ; Tipo, Vincenzo ; Da Cas, Roberto ; Traversa, Giuseppe ; Menniti-Ippolito, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b593t-c8ef19508a22855b4c08eaaf9b1c8f7a82b6e77fbf536a8b8ed25d49366a17a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetaminophen - adverse effects</topic><topic>Addictive behaviors</topic><topic>Adrenal Cortex Hormones - adverse effects</topic><topic>Adult and adolescent clinical studies</topic><topic>adverse events</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-inflammatory agents</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Antibiotics</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>case-control study</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic illnesses</topic><topic>Control Groups</topic><topic>Data Analysis</topic><topic>Drug addiction</topic><topic>Drug Therapy</topic><topic>Drug use</topic><topic>Endoscopy</topic><topic>Ethics</topic><topic>Female</topic><topic>gastrointestinal complications</topic><topic>Gastrointestinal diseases</topic><topic>Gastrointestinal Diseases - chemically induced</topic><topic>General aspects</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Italy - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Narcotics</topic><topic>Neurological disorders</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Parents</topic><topic>Pediatrics</topic><topic>Prevention and actions</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk</topic><topic>Statistical Analysis</topic><topic>Steroids</topic><topic>Surveillance</topic><topic>Toxicity</topic><topic>Upper Gastrointestinal Tract - pathology</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bianciotto, Manuela</creatorcontrib><creatorcontrib>Chiappini, Elena</creatorcontrib><creatorcontrib>Raffaldi, Irene</creatorcontrib><creatorcontrib>Gabiano, Clara</creatorcontrib><creatorcontrib>Tovo, Pier-Angelo</creatorcontrib><creatorcontrib>Sollai, Sara</creatorcontrib><creatorcontrib>de Martino, Maurizio</creatorcontrib><creatorcontrib>Mannelli, Francesco</creatorcontrib><creatorcontrib>Tipo, Vincenzo</creatorcontrib><creatorcontrib>Da Cas, Roberto</creatorcontrib><creatorcontrib>Traversa, Giuseppe</creatorcontrib><creatorcontrib>Menniti-Ippolito, Francesca</creatorcontrib><creatorcontrib>Italian Multicenter Study Group for Drug and Vaccine Safety in 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Basic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of disease in childhood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bianciotto, Manuela</au><au>Chiappini, Elena</au><au>Raffaldi, Irene</au><au>Gabiano, Clara</au><au>Tovo, Pier-Angelo</au><au>Sollai, Sara</au><au>de Martino, Maurizio</au><au>Mannelli, Francesco</au><au>Tipo, Vincenzo</au><au>Da Cas, Roberto</au><au>Traversa, Giuseppe</au><au>Menniti-Ippolito, Francesca</au><aucorp>Italian Multicenter Study Group for Drug and Vaccine Safety in Children</aucorp><aucorp>and the Italian Multicenter Study Group for Drug and Vaccine Safety in Children</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug use and upper gastrointestinal complications in children: a case–control study</atitle><jtitle>Archives of disease in childhood</jtitle><addtitle>Arch Dis Child</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>98</volume><issue>3</issue><spage>218</spage><epage>221</epage><pages>218-221</pages><issn>0003-9888</issn><eissn>1468-2044</eissn><coden>ADCHAK</coden><abstract>Objective To evaluate the risk of upper gastrointestinal complications (UGIC) associated with drug use in the paediatric population. Methods This study is part of a large Italian prospective multicentre study. The study population included children hospitalised for acute conditions through the emergency departments of eight clinical centres. Patients admitted for UGIC (defined as endoscopically confirmed gastroduodenal lesions or clinically defined haematemesis or melena) comprised the case series; children hospitalised for neurological disorders formed the control group. Information on drug and vaccine exposure was collected through parental interview during the children's hospitalisation. Logistic regression was used to estimate ORs for the occurrence of UGIC associated with drug use adjusted for age, clinical centre and concomitant use of any drug. Results 486 children hospitalised for UGIC and 1930 for neurological disorders were enrolled between November 1999 and November 2010. Drug use was higher in cases than in controls (73% vs 54%; p<0.001). UGICs were associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs) (adjusted OR 2.9, 95% CI 2.1 to 4.0), oral steroids (adjusted OR 2.9, 95% CI 1.7 to 4.8) and antibiotics (adjusted OR 2.3, 95% CI 1.8 to 3.1). The duration of use of these drug categories was short (range 1–8 days). Paracetamol showed a lower risk (adjusted OR 2.0, 95% CI 1.5 to 2.6) compared to ibuprofen (adjusted OR 3.7, 95% CI 2.3 to 5.9), although with partially overlapping CIs. Conclusions NSAIDs, oral steroids and antibiotics, even when administered for a short period, were associated with an increased risk of UGIC.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>23264432</pmid><doi>10.1136/archdischild-2012-302100</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0003-9888 |
| ispartof | Archives of disease in childhood, 2013-03, Vol.98 (3), p.218-221 |
| issn | 0003-9888 1468-2044 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3582087 |
| source | MEDLINE; BMJ Journals - NESLi2 |
| subjects | Acetaminophen - adverse effects Addictive behaviors Adrenal Cortex Hormones - adverse effects Adult and adolescent clinical studies adverse events Anti-Bacterial Agents - adverse effects Anti-inflammatory agents Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antibiotics Asthma Biological and medical sciences Case-Control Studies case-control study Child Child, Preschool Chronic illnesses Control Groups Data Analysis Drug addiction Drug Therapy Drug use Endoscopy Ethics Female gastrointestinal complications Gastrointestinal diseases Gastrointestinal Diseases - chemically induced General aspects Hospitalization Hospitals Humans Infant Italy - epidemiology Logistic Models Male Medical sciences Miscellaneous Narcotics Neurological disorders Nonsteroidal anti-inflammatory drugs Parents Pediatrics Prevention and actions Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Risk Statistical Analysis Steroids Surveillance Toxicity Upper Gastrointestinal Tract - pathology Vaccines |
| title | Drug use and upper gastrointestinal complications in children: a case–control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T20%3A05%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Drug%20use%20and%20upper%20gastrointestinal%20complications%20in%20children:%20a%20case%E2%80%93control%20study&rft.jtitle=Archives%20of%20disease%20in%20childhood&rft.au=Bianciotto,%20Manuela&rft.aucorp=Italian%20Multicenter%20Study%20Group%20for%20Drug%20and%20Vaccine%20Safety%20in%20Children&rft.date=2013-03-01&rft.volume=98&rft.issue=3&rft.spage=218&rft.epage=221&rft.pages=218-221&rft.issn=0003-9888&rft.eissn=1468-2044&rft.coden=ADCHAK&rft_id=info:doi/10.1136/archdischild-2012-302100&rft_dat=%3Cproquest_pubme%3E4214850761%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1828881281&rft_id=info:pmid/23264432&rfr_iscdi=true |