Adiponectin Corrects High-Fat Diet―Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis

We provide here a detailed and comprehensive analysis of skeletal muscle metabolomic profiles in response to adiponectin in adiponectin knockout (AdKO) mice after high-fat-diet (HFD) feeding. Hyperinsulinemic-euglycemic clamp studies showed that adiponectin administration corrected HFD-induced defec...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-03, Vol.62 (3), p.743-752
Hauptverfasser:	YING LIU, TURDI, Subat, PARK, Taesik, MORRIS, Nicholas J, DESHAIES, Yves, AIMIN XU, SWEENEY, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - genetics Adiponectin - metabolism Adipose Tissue, White - metabolism Adipose Tissue, White - ultrastructure Animals Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Diabetes. Impaired glucose tolerance Diet Diet, High-Fat - adverse effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Glucose Homeostasis Hyperlipidemias - blood Hyperlipidemias - etiology Hyperlipidemias - metabolism Hyperlipidemias - pathology Insulin - metabolism Insulin Resistance Kinases Male Medical sciences Metabolic Syndrome - blood Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Metabolism Metabolomics - methods Mice Mice, Inbred C57BL Mice, Knockout Mitochondria, Muscle - metabolism Mitochondria, Muscle - ultrastructure Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure Muscles Musculoskeletal system Obesity Obesity - blood Obesity - etiology Obesity - metabolism Obesity - pathology Physiological aspects Protein hormones Recombinant Proteins - metabolism Signal Transduction Skeletal muscle Veins & arteries
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