APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

OBJECTIVE To test for an association between the apolipoprotein E (APOE) ϵ4 allele and dementias with synucleinopathy. DESIGN Genetic case-control association study. SETTING Academic research. PATIENTS Autopsied subjects were classified into 5 categories: dementia with high-level Alzheimer disease (...

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Veröffentlicht in:	JAMA neurology 2013-02, Vol.70 (2), p.223-228
Hauptverfasser:	Tsuang, Debby, Leverenz, James B, Lopez, Oscar L, Hamilton, Ronald L, Bennett, David A, Schneider, Julie A, Buchman, Aron S, Larson, Eric B, Crane, Paul K, Kaye, Jeffrey A, Kramer, Patricia, Woltjer, Randy, Trojanowski, John Q, Weintraub, Daniel, Chen-Plotkin, Alice S, Irwin, David J, Rick, Jacqueline, Schellenberg, Gerard D, Watson, G. Stennis, Kukull, Walter, Nelson, Peter T, Jicha, Gregory A, Neltner, Janna H, Galasko, Doug, Masliah, Eliezer, Quinn, Joseph F, Chung, Kathryn A, Yearout, Dora, Mata, Ignacio F, Wan, Jia Y, Edwards, Karen L, Montine, Thomas J, Zabetian, Cyrus P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - pathology Apolipoprotein E4 - genetics Case-Control Studies Dementia - genetics Dementia - pathology Female Gene Frequency - genetics Humans Lewy Body Disease - genetics Lewy Body Disease - pathology Longitudinal Studies Male Middle Aged Parkinson Disease - genetics Parkinson Disease - pathology Retrospective Studies Risk Factors Synucleins - genetics Up-Regulation - genetics
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