Clinical and microbiological efficacy of continuous versus intermittent application of meropenem in critically ill patients: a randomized open-label controlled trial

Meropenem bactericidal activity depends on the time when the free drug concentrations remain above the minimum inhibitory concentration of pathogens. The goal of this study was to compare clinical and bacteriological efficacy of continuous meropenem infusion versus bolus administration in critically...

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Veröffentlicht in:	Critical care (London, England) England), 2012-06, Vol.16 (3), p.R113-R113, Article R113
Hauptverfasser:	Chytra, Ivan, Stepan, Martin, Benes, Jan, Pelnar, Petr, Zidkova, Alexandra, Bergerova, Tamara, Pradl, Richard, Kasal, Eduard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Bacterial Agents - administration & dosage Antibiotics Colony Count, Microbial - trends Critical Illness - mortality Critical Illness - therapy Dosage and administration Drug Administration Schedule Drug therapy Female Health aspects Hospital Mortality - trends Humans Infection Infusions, Intravenous Intensive Care Units - trends Male Microbiology Middle Aged Mortality Patient outcomes Prospective Studies Thienamycins - administration & dosage Treatment Outcome
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