Effects of early-life adversity on cognitive decline in older African Americans and whites
Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline. Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically def...
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| Veröffentlicht in: | Neurology 2012-12, Vol.79 (24), p.2321-2327 |
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| creator | BARNES, Lisa L WILSON, Robert S EVERSON-ROSE, Susan A HAYWARD, Mark D EVANS, Denis A MENDES DE LEON, Carlos F |
| description | Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline.
Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population-based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effects models.
In models stratified by race, and adjusted for age and sex, early-life adversity was differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors.
Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans. |
| doi_str_mv | 10.1212/wnl.0b013e318278b607 |
| format | Article |
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Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population-based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effects models.
In models stratified by race, and adjusted for age and sex, early-life adversity was differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors.
Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/wnl.0b013e318278b607</identifier><identifier>PMID: 23233682</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>African Americans - psychology ; Aged ; Aged, 80 and over ; Aging - psychology ; Alzheimer Disease - etiology ; Alzheimer Disease - psychology ; Biological and medical sciences ; Cognition ; Cognition Disorders - etiology ; Cognition Disorders - psychology ; Disease Progression ; European Continental Ancestry Group - psychology ; Female ; Humans ; Life Change Events ; Male ; Medical sciences ; Middle Aged ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuropsychological Tests ; Risk Factors</subject><ispartof>Neurology, 2012-12, Vol.79 (24), p.2321-2327</ispartof><rights>2014 INIST-CNRS</rights><rights>2012 American Academy of Neurology 2012 American Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-8c680f749d0b2dd95f34d964a8b2d7e9db5a7c11cf47869795e6db6dae934b693</citedby><cites>FETCH-LOGICAL-c537t-8c680f749d0b2dd95f34d964a8b2d7e9db5a7c11cf47869795e6db6dae934b693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26747903$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23233682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BARNES, Lisa L</creatorcontrib><creatorcontrib>WILSON, Robert S</creatorcontrib><creatorcontrib>EVERSON-ROSE, Susan A</creatorcontrib><creatorcontrib>HAYWARD, Mark D</creatorcontrib><creatorcontrib>EVANS, Denis A</creatorcontrib><creatorcontrib>MENDES DE LEON, Carlos F</creatorcontrib><title>Effects of early-life adversity on cognitive decline in older African Americans and whites</title><title>Neurology</title><addtitle>Neurology</addtitle><description>Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline.
Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population-based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effects models.
In models stratified by race, and adjusted for age and sex, early-life adversity was differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors.
Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans.</description><subject>African Americans - psychology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - psychology</subject><subject>Alzheimer Disease - etiology</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - psychology</subject><subject>Disease Progression</subject><subject>European Continental Ancestry Group - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Life Change Events</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Risk Factors</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctuFDEQRS0EIkPgDxDyBimbTvzo9mODNIoCiTQKGxCIjeW2y4mRxw52z0Tz93TIEB6rrKpK99RVlS5Cryk5poyyk9ucjslIKAdOFZNqFEQ-QQs6MNEJzr4-RQtCmOq4kuoAvWjtOyGzKPVzdMA441wotkDfzkIANzVcAgZb065LMQC2fgu1xWmHS8auXOU4xS1gDy7FDDhmXJKHipehRmczXq7hV9OwzR7fXscJ2kv0LNjU4NW-HqLP788-nZ53q48fLk6Xq84NXE6dckKRIHvtyci810Pgvdeit2oeJWg_DlY6Sl3opRJa6gGEH4W3oHk_Cs0P0bt735vNuAbvIE_VJnNT49rWnSk2mn-VHK_NVdkaPkjFpZgNjvYGtfzYQJvMOjYHKdkMZdMMZZoKInRPH4EqpmZfQma0v0ddLa1VCA8XUWLuEjRfLlfm_wTntTd_f_Ow9DuyGXi7B2xzNoVqs4vtDydkLzXh_Cf5x6Z4</recordid><startdate>20121211</startdate><enddate>20121211</enddate><creator>BARNES, Lisa L</creator><creator>WILSON, Robert S</creator><creator>EVERSON-ROSE, Susan A</creator><creator>HAYWARD, Mark D</creator><creator>EVANS, Denis A</creator><creator>MENDES DE LEON, Carlos F</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20121211</creationdate><title>Effects of early-life adversity on cognitive decline in older African Americans and whites</title><author>BARNES, Lisa L ; WILSON, Robert S ; EVERSON-ROSE, Susan A ; HAYWARD, Mark D ; EVANS, Denis A ; MENDES DE LEON, Carlos F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-8c680f749d0b2dd95f34d964a8b2d7e9db5a7c11cf47869795e6db6dae934b693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>African Americans - psychology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - psychology</topic><topic>Alzheimer Disease - etiology</topic><topic>Alzheimer Disease - psychology</topic><topic>Biological and medical sciences</topic><topic>Cognition</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - psychology</topic><topic>Disease Progression</topic><topic>European Continental Ancestry Group - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Life Change Events</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BARNES, Lisa L</creatorcontrib><creatorcontrib>WILSON, Robert S</creatorcontrib><creatorcontrib>EVERSON-ROSE, Susan A</creatorcontrib><creatorcontrib>HAYWARD, Mark D</creatorcontrib><creatorcontrib>EVANS, Denis A</creatorcontrib><creatorcontrib>MENDES DE LEON, Carlos F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BARNES, Lisa L</au><au>WILSON, Robert S</au><au>EVERSON-ROSE, Susan A</au><au>HAYWARD, Mark D</au><au>EVANS, Denis A</au><au>MENDES DE LEON, Carlos F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of early-life adversity on cognitive decline in older African Americans and whites</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2012-12-11</date><risdate>2012</risdate><volume>79</volume><issue>24</issue><spage>2321</spage><epage>2327</epage><pages>2321-2327</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Early-life adversity is related to adult health in old age but little is known about its relation with cognitive decline.
Participants included more than 6,100 older residents (mean age = 74.9 [7.1] years; 61.8% African American) enrolled in the Chicago Health and Aging Project, a geographically defined, population-based study of risk factors for Alzheimer disease. Participants were interviewed at approximately 3-year intervals for up to 16 years. The interview included a baseline evaluation of early-life adversity, and administration of 4 brief cognitive function tests to assess change in cognitive function. We estimated the relation of early-life adversity to rate of cognitive decline in a series of mixed-effects models.
In models stratified by race, and adjusted for age and sex, early-life adversity was differentially related to decline in African Americans and whites. Whereas no measure of early-life adversity related to cognitive decline in whites, both food deprivation and being thinner than average in early life were associated with a slower rate of cognitive decline in African Americans. The relations were not mediated by years of education and persisted after adjustment for cardiovascular factors.
Markers of early-life adversity had an unexpected protective effect on cognitive decline in African Americans.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>23233682</pmid><doi>10.1212/wnl.0b013e318278b607</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | African Americans - psychology Aged Aged, 80 and over Aging - psychology Alzheimer Disease - etiology Alzheimer Disease - psychology Biological and medical sciences Cognition Cognition Disorders - etiology Cognition Disorders - psychology Disease Progression European Continental Ancestry Group - psychology Female Humans Life Change Events Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuropsychological Tests Risk Factors |
| title | Effects of early-life adversity on cognitive decline in older African Americans and whites |
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