Genomic instability in cancer

One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur. Organisms have deve...

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Veröffentlicht in:	Cold Spring Harbor perspectives in biology 2013-03, Vol.5 (3), p.a012914-a012914
Hauptverfasser:	Abbas, Tarek, Keaton, Mignon A, Dutta, Anindya
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle Checkpoints - physiology Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology DNA Damage DNA Replication - physiology Geminin Genomic Instability - genetics Humans Minichromosome Maintenance Complex Component 2 Models, Biological Neoplasms - genetics Nuclear Proteins - metabolism Origin Recognition Complex - metabolism Ubiquitin-Protein Ligases - metabolism
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