Melittin derived peptides for nanoparticle based siRNA transfection

Abstract Traditional transfection agents including cationic lipids and polymers have high efficiency but cause cytotoxicity. While cell penetrating peptide based transfection agents exhibit improved cytotoxicity profiles, they do not have the efficiency of existing lipidic agents due to endosomal tr...

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Veröffentlicht in:	Biomaterials 2013-04, Vol.34 (12), p.3110-3119
Hauptverfasser:	Hou, Kirk K, Pan, Hua, Lanza, Gregory M, Wickline, Samuel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Cell Line Cell Line, Tumor Dentistry Drug delivery Endothelial cell Flow Cytometry Gene therapy Humans Macrophage Melitten - chemistry Mice Nanoparticle Nanoparticles Peptides - administration & dosage Peptides - chemistry Real-Time Polymerase Chain Reaction RNA, Small Interfering - genetics Transfection
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