Stability of whole inactivated influenza virus vaccine during coating onto metal microneedles

Immunization using a microneedle patch coated with vaccine offers the promise of simplified vaccination logistics and increased vaccine immunogenicity. This study examined the stability of influenza vaccine during the microneedle coating process, with a focus on the role of coating formulation excip...

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Veröffentlicht in:	Journal of controlled release 2013-03, Vol.166 (2), p.159-171
Hauptverfasser:	Choi, Hyo-Jick, Bondy, Brian J., Yoo, Dae-Goon, Compans, Richard W., Kang, Sang-Moo, Prausnitz, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibodies carboxymethylcellulose Chemistry, Pharmaceutical Coated microneedle patch Coating formulation coatings Crystallization Drug Stability drying Female hemagglutinins Humans hydrophilicity immune response Immunization influenza Influenza A virus - immunology Influenza vaccine stability Influenza Vaccines - administration & dosage Influenza Vaccines - chemistry Influenza Vaccines - immunology Influenza virus Influenza, Human - immunology Influenza, Human - prevention & control Light Metals Mice Mice, Inbred BALB C Microscopy, Electron, Transmission Nanotechnology Needles Orthomyxoviridae Osmosis Osmotic pressure Phase separation Scattering, Radiation separation surfactants survival rate Titanium trehalose vaccination vaccines Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - chemistry Viscosity Water - analysis X-Ray Diffraction
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