Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury
Abstract Background Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury usin...
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| Veröffentlicht in: | The Journal of surgical research 2013-03, Vol.180 (1), p.35-42 |
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| creator | Havelka, George E., MD Moreira, Edward S., PhD Rodriguez, Monica P., MD Tsihlis, Nick D., PhD Wang, Zheng Martínez, Janet, AAS Hrabie, Joseph A., PhD Kiefer, Larry K., PhD Kibbe, Melina R., MD |
| description | Abstract Background Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury using a permeable balloon catheter. Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia. Materials and methods Ten-week-old male Sprague-Dawley rats underwent carotid artery balloon injury. Groups included: (1) control, (2) injury, (3) injury + periadventitial NO, and (4) injury + endoluminal NO via permeable balloon catheter. The catheter was inflated to 5 atm pressure for 5 min. Arteries were harvested 2 wk following injury. Morphometric assessment for neointimal hyperplasia and immunohistochemical staining for inflammatory markers were performed. Results Injury increased neointimal hyperplasia compared with control (intima/media area [I/M] ratio 1.07 versus 0.11, respectively, P < 0.001). Periadventitial delivery of NO reduced the I/M area ratio compared with injury alone (55% decrease, P < 0.001). Endoluminal delivery of NO also reduced the I/M area ratio compared with injury alone (65% decrease; P < 0.001). Both endoluminal and periadventitial NO affected the I/M ratio by reducing the intimal area (64% and 46%, respectively, P < 0.001) whereas neither affected the medial area. Periadventitial NO delivery increased lumen area ( P < 0.05), whereas endoluminal NO delivery increased circumference ( P < 0.05). Periadventitial NO delivery inhibited macrophage intimal infiltration compared with injury alone ( P < 0.05). Conclusions These data demonstrate that short-duration endoluminal NO delivery via permeable balloon catheters inhibits neointimal hyperplasia following arterial interventions. Endoluminal delivery of NO could become a focus for future clinical interventions. |
| doi_str_mv | 10.1016/j.jss.2012.10.048 |
| format | Article |
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Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury using a permeable balloon catheter. Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia. Materials and methods Ten-week-old male Sprague-Dawley rats underwent carotid artery balloon injury. Groups included: (1) control, (2) injury, (3) injury + periadventitial NO, and (4) injury + endoluminal NO via permeable balloon catheter. The catheter was inflated to 5 atm pressure for 5 min. Arteries were harvested 2 wk following injury. Morphometric assessment for neointimal hyperplasia and immunohistochemical staining for inflammatory markers were performed. Results Injury increased neointimal hyperplasia compared with control (intima/media area [I/M] ratio 1.07 versus 0.11, respectively, P < 0.001). Periadventitial delivery of NO reduced the I/M area ratio compared with injury alone (55% decrease, P < 0.001). Endoluminal delivery of NO also reduced the I/M area ratio compared with injury alone (65% decrease; P < 0.001). Both endoluminal and periadventitial NO affected the I/M ratio by reducing the intimal area (64% and 46%, respectively, P < 0.001) whereas neither affected the medial area. Periadventitial NO delivery increased lumen area ( P < 0.05), whereas endoluminal NO delivery increased circumference ( P < 0.05). Periadventitial NO delivery inhibited macrophage intimal infiltration compared with injury alone ( P < 0.05). Conclusions These data demonstrate that short-duration endoluminal NO delivery via permeable balloon catheters inhibits neointimal hyperplasia following arterial interventions. Endoluminal delivery of NO could become a focus for future clinical interventions.]]></description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2012.10.048</identifier><identifier>PMID: 23164361</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adventitia ; Angioplasty, Balloon ; Animals ; Carotid Artery Injuries - drug therapy ; Carotid Artery Injuries - pathology ; Endoluminal ; Hyperplasia ; Inflammation ; Intima ; Macrophage ; Male ; Media ; Neointima - pathology ; Neointimal hyperplasia ; Nitric oxide ; Nitric Oxide - administration & dosage ; Permeability ; Rats ; Rats, Sprague-Dawley ; Restenosis ; Surgery</subject><ispartof>The Journal of surgical research, 2013-03, Vol.180 (1), p.35-42</ispartof><rights>2013</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-160e842c7a8085798e3ad98d01a7e844c73efc14997ac704b115601c0f7487a83</citedby><cites>FETCH-LOGICAL-c506t-160e842c7a8085798e3ad98d01a7e844c73efc14997ac704b115601c0f7487a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022480412009687$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23164361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Havelka, George E., MD</creatorcontrib><creatorcontrib>Moreira, Edward S., PhD</creatorcontrib><creatorcontrib>Rodriguez, Monica P., MD</creatorcontrib><creatorcontrib>Tsihlis, Nick D., PhD</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Martínez, Janet, AAS</creatorcontrib><creatorcontrib>Hrabie, Joseph A., PhD</creatorcontrib><creatorcontrib>Kiefer, Larry K., PhD</creatorcontrib><creatorcontrib>Kibbe, Melina R., MD</creatorcontrib><title>Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description><![CDATA[Abstract Background Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury using a permeable balloon catheter. Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia. Materials and methods Ten-week-old male Sprague-Dawley rats underwent carotid artery balloon injury. Groups included: (1) control, (2) injury, (3) injury + periadventitial NO, and (4) injury + endoluminal NO via permeable balloon catheter. The catheter was inflated to 5 atm pressure for 5 min. Arteries were harvested 2 wk following injury. Morphometric assessment for neointimal hyperplasia and immunohistochemical staining for inflammatory markers were performed. Results Injury increased neointimal hyperplasia compared with control (intima/media area [I/M] ratio 1.07 versus 0.11, respectively, P < 0.001). Periadventitial delivery of NO reduced the I/M area ratio compared with injury alone (55% decrease, P < 0.001). Endoluminal delivery of NO also reduced the I/M area ratio compared with injury alone (65% decrease; P < 0.001). Both endoluminal and periadventitial NO affected the I/M ratio by reducing the intimal area (64% and 46%, respectively, P < 0.001) whereas neither affected the medial area. Periadventitial NO delivery increased lumen area ( P < 0.05), whereas endoluminal NO delivery increased circumference ( P < 0.05). Periadventitial NO delivery inhibited macrophage intimal infiltration compared with injury alone ( P < 0.05). Conclusions These data demonstrate that short-duration endoluminal NO delivery via permeable balloon catheters inhibits neointimal hyperplasia following arterial interventions. Endoluminal delivery of NO could become a focus for future clinical interventions.]]></description><subject>Adventitia</subject><subject>Angioplasty, Balloon</subject><subject>Animals</subject><subject>Carotid Artery Injuries - drug therapy</subject><subject>Carotid Artery Injuries - pathology</subject><subject>Endoluminal</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Intima</subject><subject>Macrophage</subject><subject>Male</subject><subject>Media</subject><subject>Neointima - pathology</subject><subject>Neointimal hyperplasia</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - administration & dosage</subject><subject>Permeability</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Restenosis</subject><subject>Surgery</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2P0zAQjRCILQs_gAvykUvKOE5iR0groRVf0goOwNlynGk7wY2L7XTpv8dRlxVw4GLLM--9Gc-bonjOYc2Bt6_G9RjjugJe5fcaavWgWHHomlK1UjwsVgBVVdYK6oviSYwj5HcnxePiohK8rUXLV8X2E6VAlvmfNCAb0NERw4kdyTDDDhj2aHqHrDfOeT8xa9IOEwZG0456SpFN6GlKtDeObYO_TTtmNgvAhHxSjtI0zuH0tHi0MS7is7v7svj27u3X6w_lzef3H6_f3JS2gTaVvAVUdWWlUaAa2SkUZujUANzInKitFLixvO46aayEuue8aYFb2MhaZZK4LK7Ouoe53-NgcUrBOH0IucNw0t6Q_jsz0U5v_VGLRioAmQVe3gkE_2PGmPSeokXnTP7pHDWvlOo60YmlFj9DbfAxBtzcl-GgF4P0qLNBejFoCWWDMufFn_3dM347kgGvzwDMUzoSBh0t4WRxoIA26cHTf-Wv_mFbRxNZ477jCePo5zDl8WuuY6VBf1k2ZFkQXgF0rZLiFz4GuAQ</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Havelka, George E., MD</creator><creator>Moreira, Edward S., PhD</creator><creator>Rodriguez, Monica P., MD</creator><creator>Tsihlis, Nick D., PhD</creator><creator>Wang, Zheng</creator><creator>Martínez, Janet, AAS</creator><creator>Hrabie, Joseph A., PhD</creator><creator>Kiefer, Larry K., PhD</creator><creator>Kibbe, Melina R., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130301</creationdate><title>Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury</title><author>Havelka, George E., MD ; Moreira, Edward S., PhD ; Rodriguez, Monica P., MD ; Tsihlis, Nick D., PhD ; Wang, Zheng ; Martínez, Janet, AAS ; Hrabie, Joseph A., PhD ; Kiefer, Larry K., PhD ; Kibbe, Melina R., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-160e842c7a8085798e3ad98d01a7e844c73efc14997ac704b115601c0f7487a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adventitia</topic><topic>Angioplasty, Balloon</topic><topic>Animals</topic><topic>Carotid Artery Injuries - drug therapy</topic><topic>Carotid Artery Injuries - pathology</topic><topic>Endoluminal</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>Intima</topic><topic>Macrophage</topic><topic>Male</topic><topic>Media</topic><topic>Neointima - pathology</topic><topic>Neointimal hyperplasia</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - administration & dosage</topic><topic>Permeability</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Restenosis</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Havelka, George E., MD</creatorcontrib><creatorcontrib>Moreira, Edward S., PhD</creatorcontrib><creatorcontrib>Rodriguez, Monica P., MD</creatorcontrib><creatorcontrib>Tsihlis, Nick D., PhD</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Martínez, Janet, AAS</creatorcontrib><creatorcontrib>Hrabie, Joseph A., PhD</creatorcontrib><creatorcontrib>Kiefer, Larry K., PhD</creatorcontrib><creatorcontrib>Kibbe, Melina R., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Havelka, George E., MD</au><au>Moreira, Edward S., PhD</au><au>Rodriguez, Monica P., MD</au><au>Tsihlis, Nick D., PhD</au><au>Wang, Zheng</au><au>Martínez, Janet, AAS</au><au>Hrabie, Joseph A., PhD</au><au>Kiefer, Larry K., PhD</au><au>Kibbe, Melina R., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>180</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract><![CDATA[Abstract Background Neointimal hyperplasia limits the longevity of vascular interventions. Nitric oxide (NO) is well known to inhibit neointimal hyperplasia. However, delivery of NO to the vasculature is challenging. Our study aims to evaluate the efficacy of delivering NO to the site of injury using a permeable balloon catheter. Our hypothesis is that ultra-short duration NO delivery using a permeable balloon catheter will inhibit neointimal hyperplasia. Materials and methods Ten-week-old male Sprague-Dawley rats underwent carotid artery balloon injury. Groups included: (1) control, (2) injury, (3) injury + periadventitial NO, and (4) injury + endoluminal NO via permeable balloon catheter. The catheter was inflated to 5 atm pressure for 5 min. Arteries were harvested 2 wk following injury. Morphometric assessment for neointimal hyperplasia and immunohistochemical staining for inflammatory markers were performed. Results Injury increased neointimal hyperplasia compared with control (intima/media area [I/M] ratio 1.07 versus 0.11, respectively, P < 0.001). Periadventitial delivery of NO reduced the I/M area ratio compared with injury alone (55% decrease, P < 0.001). Endoluminal delivery of NO also reduced the I/M area ratio compared with injury alone (65% decrease; P < 0.001). Both endoluminal and periadventitial NO affected the I/M ratio by reducing the intimal area (64% and 46%, respectively, P < 0.001) whereas neither affected the medial area. Periadventitial NO delivery increased lumen area ( P < 0.05), whereas endoluminal NO delivery increased circumference ( P < 0.05). Periadventitial NO delivery inhibited macrophage intimal infiltration compared with injury alone ( P < 0.05). Conclusions These data demonstrate that short-duration endoluminal NO delivery via permeable balloon catheters inhibits neointimal hyperplasia following arterial interventions. Endoluminal delivery of NO could become a focus for future clinical interventions.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23164361</pmid><doi>10.1016/j.jss.2012.10.048</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adventitia Angioplasty, Balloon Animals Carotid Artery Injuries - drug therapy Carotid Artery Injuries - pathology Endoluminal Hyperplasia Inflammation Intima Macrophage Male Media Neointima - pathology Neointimal hyperplasia Nitric oxide Nitric Oxide - administration & dosage Permeability Rats Rats, Sprague-Dawley Restenosis Surgery |
| title | Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury |
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