Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists

Previous studies have established that pro-oxidative stressors suppress host immunity because of their ability to generate oxidized lipids with platelet-activating factor receptor (PAF-R) agonist activity. Although exposure to the pro-oxidative stressor cigarette smoke (CS) is known to exert immunom...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-03, Vol.190 (5), p.2447-2454
Hauptverfasser:	Sahu, Ravi P, Petrache, Irina, Van Demark, Mary J, Rashid, Badri M, Ocana, Jesus A, Tang, Yuxuan, Yi, Qiaofang, Turner, Matthew J, Konger, Raymond L, Travers, Jeffrey B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dermatitis, Contact - immunology Dermatitis, Contact - metabolism Dermatitis, Contact - pathology Dinitrofluorobenzene Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression - drug effects Glycerylphosphorylcholine - immunology Glycerylphosphorylcholine - metabolism Hydrolases - metabolism Immunosuppression Therapy Lipid Peroxidation - drug effects Lymphocyte Depletion Mice Mice, Transgenic Nicotiana - adverse effects Platelet Activating Factor - genetics Platelet Activating Factor - metabolism Platelet Membrane Glycoproteins - agonists Platelet Membrane Glycoproteins - genetics Platelet Membrane Glycoproteins - metabolism Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Smoke - adverse effects T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology
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