Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

Brian Oliver, Jason Lieb, Christine Disteche and colleagues present an analysis of expression data in mammals, C. elegans and Drosophila . They conclude that dosage compensation corrects the imbalance in the number of X chromosomes relative to autosomes by upregulating X-linked genes in both males a...

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Veröffentlicht in:	Nature genetics 2011-12, Vol.43 (12), p.1179-1185
Hauptverfasser:	Deng, Xinxian, Hiatt, Joseph B, Nguyen, Di Kim, Ercan, Sevinc, Sturgill, David, Hillier, LaDeana W, Schlesinger, Felix, Davis, Carrie A, Reinke, Valerie J, Gingeras, Thomas R, Shendure, Jay, Waterston, Robert H, Oliver, Brian, Lieb, Jason D, Disteche, Christine M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/176/1433 631/208/200 Agriculture analysis Animal Genetics and Genomics Animal species Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Caenorhabditis elegans Caenorhabditis elegans - genetics Cancer Research Cell Line Chromosomes Compensation Dosage Compensation, Genetic Drosophila Drosophila melanogaster Drosophila melanogaster - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation Gene Function Genes, X-Linked Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Human Genetics Humans Male Mammals Mice Oligonucleotide Array Sequence Analysis Organ Specificity Ovary - metabolism Physiological aspects Proteins RNA Polymerase II - metabolism Studies Testis - metabolism Transcription, Genetic Up-Regulation X chromosome X Chromosome - genetics
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