mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

Lack of IGF2 in mice results in diminished embryonic growth due to diminished cell proliferation. Here we show that mouse embryonic fibroblasts lacking the RNA-binding protein IMP1 (IGF2 mRNA-binding protein 1) have defective splicing and translation of IGF2 mRNAs, markedly reduced IGF2 polypeptide...

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Veröffentlicht in:	Genes & development 2013-02, Vol.27 (3), p.301-312
Hauptverfasser:	Dai, Ning, Christiansen, Jan, Nielsen, Finn C, Avruch, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics Animals Cell Line Cell Proliferation Fibroblasts - cytology Gene Expression Regulation, Developmental Insulin-Like Growth Factor II - genetics Insulin-Like Growth Factor II - metabolism Mechanistic Target of Rapamycin Complex 2 Mice Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Phosphorylation Protein Binding Research Paper Reticulocytes - metabolism RNA Splicing RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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