A new structural framework for integrating replication protein A into DNA processing machinery

By coupling the protection and organization of single-stranded DNA (ssDNA) with recruitment and alignment of DNA processing factors, replication protein A (RPA) lies at the heart of dynamic multi-protein DNA processing machinery. Nevertheless, how RPA coordinates biochemical functions of its eight d...

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Veröffentlicht in:	Nucleic acids research 2013-02, Vol.41 (4), p.2313-2327
Hauptverfasser:	Brosey, Chris A, Yan, Chunli, Tsutakawa, Susan E, Heller, William T, Rambo, Robert P, Tainer, John A, Ivanov, Ivaylo, Chazin, Walter J
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism Genome Integrity, Repair and Molecular Dynamics Simulation Neutron Diffraction Protein Binding Protein Structure, Tertiary Replication Protein A - chemistry Replication Protein A - metabolism Scattering, Small Angle X-Ray Diffraction
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