The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

Despite the critical contributions of cilia to embryonic development and human health, key regulators of cilia formation await identification. In this paper, a functional RNA interference-based screen linked 30 novel protein kinases with ciliogenesis. Of them, we have studied the role of the microtu...

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Veröffentlicht in:	The Journal of cell biology 2013-02, Vol.200 (4), p.505-522
Hauptverfasser:	Kuhns, Stefanie, Schmidt, Kerstin N, Reymann, Jürgen, Gilbert, Daniel F, Neuner, Annett, Hub, Birgit, Carvalho, Ricardo, Wiedemann, Philipp, Zentgraf, Hanswalter, Erfle, Holger, Klingmüller, Ursula, Boutros, Michael, Pereira, Gislene
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axoneme - metabolism Axoneme - ultrastructure Cell Cycle Proteins - metabolism Cell Line Cellular biology Cilia - metabolism Cilia - ultrastructure Embryology Heat-Shock Proteins - genetics Heat-Shock Proteins - physiology HEK293 Cells Humans Kinases Mice Microtubule-Associated Proteins - metabolism Models, Biological NIH 3T3 Cells Phosphoproteins - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology RNA Interference RNA-protein interactions
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