Role for the obesity-related FTO gene in the cellular sensing of amino acids

SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity. While it is not yet formally established that this effect is mediated through the actions of the FTO protein itself, loss of function mutations in FTO or its murine homologue Fto result in s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (7), p.2557-2562
Hauptverfasser:	Gulati, Pawan, Cheung, Man Ka, Antrobus, Robin, Church, Chris D., Harding, Heather P., Tung, Yi-Chun Loraine, Rimmington, Debra, Ma, Marcella, Ron, David, Lehner, Paul J., Ashcroft, Frances M., Cox, Roger D., Coll, Anthony P., O'Rahilly, Stephen, Yeo, Giles S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Ketoglutarate-Dependent Dioxygenase FTO Amino acids Amino Acids - metabolism Animals Antibodies Biological Sciences body composition Body Composition - genetics Body fat Cell extracts Cell Fractionation Chromatography, Liquid Electrophoresis, Polyacrylamide Gel Fibroblasts Food intake Fractionation gene overexpression growth retardation HEK293 Cells Humans Immunoprecipitation introns Messenger RNA Mice Mutation Obesity Obesity - genetics Polymorphism, Single Nucleotide - genetics Proteins - genetics Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents Signal Transduction - genetics single nucleotide polymorphism Tandem Mass Spectrometry TOR Serine-Threonine Kinases - metabolism Transfection Western blotting
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