Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway

Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammator...

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Veröffentlicht in:	The FASEB journal 2013-03, Vol.27 (3), p.1084-1094
Hauptverfasser:	Lucas, Christopher D., Allen, Keith C., Dorward, David A., Hoodless, Laura J., Melrose, Lauren A., Marwick, John A., Tucker, Carl S., Haslett, Christopher, Duffin, Rodger, Rossi, Adriano G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Caspase 3 - metabolism Caspase 9 - metabolism Caspase Inhibitors - pharmacology Cell Survival - drug effects Danio rerio Dose-Response Relationship, Drug Down-Regulation - drug effects Female Flavones - pharmacology Humans inflammation Male Myeloid Cell Leukemia Sequence 1 Protein polyphenols Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins c-bcl-2 - biosynthesis Quinolines - pharmacology Research Communications resolution Zebrafish
Online-Zugang:	Volltext
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