Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway
Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammator...
Gespeichert in:
| Veröffentlicht in: | The FASEB journal 2013-03, Vol.27 (3), p.1084-1094 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1094 |
|---|---|
| container_issue | 3 |
| container_start_page | 1084 |
| container_title | The FASEB journal |
| container_volume | 27 |
| creator | Lucas, Christopher D. Allen, Keith C. Dorward, David A. Hoodless, Laura J. Melrose, Lauren A. Marwick, John A. Tucker, Carl S. Haslett, Christopher Duffin, Rodger Rossi, Adriano G. |
| description | Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammatory effects in preclinical models of inflammation. Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic inflammation in vivo. Human neutrophil apoptosis was assessed morphologically and by flow cytometry following incubation with apigenin, luteolin, and wogonin. All three flavones induced time‐ and concentration‐dependent neutrophil apoptosis (apigenin, EC50=12.2 μM; luteolin, EC50=14.6 μM; and wogonin, EC50=28.9 μM). Induction of apoptosis was caspase dependent, as it was blocked by the broad‐spectrum caspase inhibitor Q‐VD‐OPh and was associated with both caspase‐3 and caspase‐9 activation. Flavone‐induced apoptosis was preceded by down‐regulation of the prosurvival protein Mcl‐1, with proteasomal inhibition preventing flavone‐induced Mcl‐1 down‐regulation and apoptosis. The flavones abrogated the survival effects of mediators that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and granulocyte‐macrophage colony stimulating factor, by driving apoptosis. Furthermore, wogonin enhanced resolution of established neutrophilic inflammation in a zebrafish model of sterile tissue injury. Wogonin‐induced resolution was dependent on apoptosis in vivo as it was blocked by caspase inhibition. Our data show that the flavones induce neutrophil apoptosis and have potential as neutrophil apoptosis‐inducing anti‐inflammatory, proresolution agents.—Lucas, C. D., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R., Rossi, A. G. Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway. FASEB J. 27, 1084–1094 (2013). www.fasebj.org |
| doi_str_mv | 10.1096/fj.12-218990 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3574292</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1551632592</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4273-cb55cd274575427068f60c59294357abccc0f8a0735d0bbec3183bf8d5fdbfa3</originalsourceid><addsrcrecordid>eNp9kb1uFDEURi0EIkugSx25TMGEa3vsmWkihYgFpCAK0lse_2S98toTe2ZX2_EIPCNPwoRNItJQWfp8dO7V_RA6IXBOoBMf3Pqc0IqStuvgBVoQzqASrYCXaAFtRyshWHuE3pSyBgACRLxGR5SRjgOrF2i9DGqboi3YRzNpi6OdxpyGlQ9YDWkYU_EF93ts0i7-_vkr29spqNGniJPD33SYM4K3XmGFh5xGq0raqPvU2MFGY-OIBzWudmr_Fr1yKhT77uE9RjfLTzdXX6rr75-_Xl1eV7qmDat0z7k2tKl5w-cAROsEaN7Rrma8Ub3WGlyroGHcQN9bzUjLetca7kzvFDtGFwftMPUba_S8QVZBDtlvVN7LpLx8_hP9St6mrZztNe3oLDh7EOR0N9kyyo0v2oagok1TkYRzIhjlf9H3B1TnVEq27mkMAXnfjnRrSag8tDPjp_-u9gQ_1jEDzQHY-WD3_5XJ5Y-PFOb7AAPK2B_CjqD7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1551632592</pqid></control><display><type>article</type><title>Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Lucas, Christopher D. ; Allen, Keith C. ; Dorward, David A. ; Hoodless, Laura J. ; Melrose, Lauren A. ; Marwick, John A. ; Tucker, Carl S. ; Haslett, Christopher ; Duffin, Rodger ; Rossi, Adriano G.</creator><creatorcontrib>Lucas, Christopher D. ; Allen, Keith C. ; Dorward, David A. ; Hoodless, Laura J. ; Melrose, Lauren A. ; Marwick, John A. ; Tucker, Carl S. ; Haslett, Christopher ; Duffin, Rodger ; Rossi, Adriano G.</creatorcontrib><description>Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammatory effects in preclinical models of inflammation. Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic inflammation in vivo. Human neutrophil apoptosis was assessed morphologically and by flow cytometry following incubation with apigenin, luteolin, and wogonin. All three flavones induced time‐ and concentration‐dependent neutrophil apoptosis (apigenin, EC50=12.2 μM; luteolin, EC50=14.6 μM; and wogonin, EC50=28.9 μM). Induction of apoptosis was caspase dependent, as it was blocked by the broad‐spectrum caspase inhibitor Q‐VD‐OPh and was associated with both caspase‐3 and caspase‐9 activation. Flavone‐induced apoptosis was preceded by down‐regulation of the prosurvival protein Mcl‐1, with proteasomal inhibition preventing flavone‐induced Mcl‐1 down‐regulation and apoptosis. The flavones abrogated the survival effects of mediators that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and granulocyte‐macrophage colony stimulating factor, by driving apoptosis. Furthermore, wogonin enhanced resolution of established neutrophilic inflammation in a zebrafish model of sterile tissue injury. Wogonin‐induced resolution was dependent on apoptosis in vivo as it was blocked by caspase inhibition. Our data show that the flavones induce neutrophil apoptosis and have potential as neutrophil apoptosis‐inducing anti‐inflammatory, proresolution agents.—Lucas, C. D., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R., Rossi, A. G. Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway. FASEB J. 27, 1084–1094 (2013). www.fasebj.org</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.12-218990</identifier><identifier>PMID: 23195034</identifier><language>eng</language><publisher>Bethesda, MD, USA: Federation of American Societies for Experimental Biology</publisher><subject>Amino Acid Chloromethyl Ketones - pharmacology ; Animals ; Anti-Inflammatory Agents - pharmacology ; Apoptosis - drug effects ; Caspase 3 - metabolism ; Caspase 9 - metabolism ; Caspase Inhibitors - pharmacology ; Cell Survival - drug effects ; Danio rerio ; Dose-Response Relationship, Drug ; Down-Regulation - drug effects ; Female ; Flavones - pharmacology ; Humans ; inflammation ; Male ; Myeloid Cell Leukemia Sequence 1 Protein ; polyphenols ; Proteasome Endopeptidase Complex - metabolism ; Proto-Oncogene Proteins c-bcl-2 - biosynthesis ; Quinolines - pharmacology ; Research Communications ; resolution ; Zebrafish</subject><ispartof>The FASEB journal, 2013-03, Vol.27 (3), p.1084-1094</ispartof><rights>FASEB</rights><rights>FASEB 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4273-cb55cd274575427068f60c59294357abccc0f8a0735d0bbec3183bf8d5fdbfa3</citedby><cites>FETCH-LOGICAL-c4273-cb55cd274575427068f60c59294357abccc0f8a0735d0bbec3183bf8d5fdbfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1096%2Ffj.12-218990$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1096%2Ffj.12-218990$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23195034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucas, Christopher D.</creatorcontrib><creatorcontrib>Allen, Keith C.</creatorcontrib><creatorcontrib>Dorward, David A.</creatorcontrib><creatorcontrib>Hoodless, Laura J.</creatorcontrib><creatorcontrib>Melrose, Lauren A.</creatorcontrib><creatorcontrib>Marwick, John A.</creatorcontrib><creatorcontrib>Tucker, Carl S.</creatorcontrib><creatorcontrib>Haslett, Christopher</creatorcontrib><creatorcontrib>Duffin, Rodger</creatorcontrib><creatorcontrib>Rossi, Adriano G.</creatorcontrib><title>Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammatory effects in preclinical models of inflammation. Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic inflammation in vivo. Human neutrophil apoptosis was assessed morphologically and by flow cytometry following incubation with apigenin, luteolin, and wogonin. All three flavones induced time‐ and concentration‐dependent neutrophil apoptosis (apigenin, EC50=12.2 μM; luteolin, EC50=14.6 μM; and wogonin, EC50=28.9 μM). Induction of apoptosis was caspase dependent, as it was blocked by the broad‐spectrum caspase inhibitor Q‐VD‐OPh and was associated with both caspase‐3 and caspase‐9 activation. Flavone‐induced apoptosis was preceded by down‐regulation of the prosurvival protein Mcl‐1, with proteasomal inhibition preventing flavone‐induced Mcl‐1 down‐regulation and apoptosis. The flavones abrogated the survival effects of mediators that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and granulocyte‐macrophage colony stimulating factor, by driving apoptosis. Furthermore, wogonin enhanced resolution of established neutrophilic inflammation in a zebrafish model of sterile tissue injury. Wogonin‐induced resolution was dependent on apoptosis in vivo as it was blocked by caspase inhibition. Our data show that the flavones induce neutrophil apoptosis and have potential as neutrophil apoptosis‐inducing anti‐inflammatory, proresolution agents.—Lucas, C. D., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R., Rossi, A. G. Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway. FASEB J. 27, 1084–1094 (2013). www.fasebj.org</description><subject>Amino Acid Chloromethyl Ketones - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase 9 - metabolism</subject><subject>Caspase Inhibitors - pharmacology</subject><subject>Cell Survival - drug effects</subject><subject>Danio rerio</subject><subject>Dose-Response Relationship, Drug</subject><subject>Down-Regulation - drug effects</subject><subject>Female</subject><subject>Flavones - pharmacology</subject><subject>Humans</subject><subject>inflammation</subject><subject>Male</subject><subject>Myeloid Cell Leukemia Sequence 1 Protein</subject><subject>polyphenols</subject><subject>Proteasome Endopeptidase Complex - metabolism</subject><subject>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</subject><subject>Quinolines - pharmacology</subject><subject>Research Communications</subject><subject>resolution</subject><subject>Zebrafish</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kb1uFDEURi0EIkugSx25TMGEa3vsmWkihYgFpCAK0lse_2S98toTe2ZX2_EIPCNPwoRNItJQWfp8dO7V_RA6IXBOoBMf3Pqc0IqStuvgBVoQzqASrYCXaAFtRyshWHuE3pSyBgACRLxGR5SRjgOrF2i9DGqboi3YRzNpi6OdxpyGlQ9YDWkYU_EF93ts0i7-_vkr29spqNGniJPD33SYM4K3XmGFh5xGq0raqPvU2MFGY-OIBzWudmr_Fr1yKhT77uE9RjfLTzdXX6rr75-_Xl1eV7qmDat0z7k2tKl5w-cAROsEaN7Rrma8Ub3WGlyroGHcQN9bzUjLetca7kzvFDtGFwftMPUba_S8QVZBDtlvVN7LpLx8_hP9St6mrZztNe3oLDh7EOR0N9kyyo0v2oagok1TkYRzIhjlf9H3B1TnVEq27mkMAXnfjnRrSag8tDPjp_-u9gQ_1jEDzQHY-WD3_5XJ5Y-PFOb7AAPK2B_CjqD7</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Lucas, Christopher D.</creator><creator>Allen, Keith C.</creator><creator>Dorward, David A.</creator><creator>Hoodless, Laura J.</creator><creator>Melrose, Lauren A.</creator><creator>Marwick, John A.</creator><creator>Tucker, Carl S.</creator><creator>Haslett, Christopher</creator><creator>Duffin, Rodger</creator><creator>Rossi, Adriano G.</creator><general>Federation of American Societies for Experimental Biology</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>L.G</scope><scope>5PM</scope></search><sort><creationdate>201303</creationdate><title>Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway</title><author>Lucas, Christopher D. ; Allen, Keith C. ; Dorward, David A. ; Hoodless, Laura J. ; Melrose, Lauren A. ; Marwick, John A. ; Tucker, Carl S. ; Haslett, Christopher ; Duffin, Rodger ; Rossi, Adriano G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4273-cb55cd274575427068f60c59294357abccc0f8a0735d0bbec3183bf8d5fdbfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino Acid Chloromethyl Ketones - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Caspase 3 - metabolism</topic><topic>Caspase 9 - metabolism</topic><topic>Caspase Inhibitors - pharmacology</topic><topic>Cell Survival - drug effects</topic><topic>Danio rerio</topic><topic>Dose-Response Relationship, Drug</topic><topic>Down-Regulation - drug effects</topic><topic>Female</topic><topic>Flavones - pharmacology</topic><topic>Humans</topic><topic>inflammation</topic><topic>Male</topic><topic>Myeloid Cell Leukemia Sequence 1 Protein</topic><topic>polyphenols</topic><topic>Proteasome Endopeptidase Complex - metabolism</topic><topic>Proto-Oncogene Proteins c-bcl-2 - biosynthesis</topic><topic>Quinolines - pharmacology</topic><topic>Research Communications</topic><topic>resolution</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucas, Christopher D.</creatorcontrib><creatorcontrib>Allen, Keith C.</creatorcontrib><creatorcontrib>Dorward, David A.</creatorcontrib><creatorcontrib>Hoodless, Laura J.</creatorcontrib><creatorcontrib>Melrose, Lauren A.</creatorcontrib><creatorcontrib>Marwick, John A.</creatorcontrib><creatorcontrib>Tucker, Carl S.</creatorcontrib><creatorcontrib>Haslett, Christopher</creatorcontrib><creatorcontrib>Duffin, Rodger</creatorcontrib><creatorcontrib>Rossi, Adriano G.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucas, Christopher D.</au><au>Allen, Keith C.</au><au>Dorward, David A.</au><au>Hoodless, Laura J.</au><au>Melrose, Lauren A.</au><au>Marwick, John A.</au><au>Tucker, Carl S.</au><au>Haslett, Christopher</au><au>Duffin, Rodger</au><au>Rossi, Adriano G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2013-03</date><risdate>2013</risdate><volume>27</volume><issue>3</issue><spage>1084</spage><epage>1094</epage><pages>1084-1094</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases. Enhancing neutrophil apoptosis has proresolution and anti‐inflammatory effects in preclinical models of inflammation. Here we investigate the ability of the flavones apigenin, luteolin, and wogonin to induce neutrophil apoptosis in vitro and resolve neutrophilic inflammation in vivo. Human neutrophil apoptosis was assessed morphologically and by flow cytometry following incubation with apigenin, luteolin, and wogonin. All three flavones induced time‐ and concentration‐dependent neutrophil apoptosis (apigenin, EC50=12.2 μM; luteolin, EC50=14.6 μM; and wogonin, EC50=28.9 μM). Induction of apoptosis was caspase dependent, as it was blocked by the broad‐spectrum caspase inhibitor Q‐VD‐OPh and was associated with both caspase‐3 and caspase‐9 activation. Flavone‐induced apoptosis was preceded by down‐regulation of the prosurvival protein Mcl‐1, with proteasomal inhibition preventing flavone‐induced Mcl‐1 down‐regulation and apoptosis. The flavones abrogated the survival effects of mediators that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and granulocyte‐macrophage colony stimulating factor, by driving apoptosis. Furthermore, wogonin enhanced resolution of established neutrophilic inflammation in a zebrafish model of sterile tissue injury. Wogonin‐induced resolution was dependent on apoptosis in vivo as it was blocked by caspase inhibition. Our data show that the flavones induce neutrophil apoptosis and have potential as neutrophil apoptosis‐inducing anti‐inflammatory, proresolution agents.—Lucas, C. D., Allen, K. C., Dorward, D. A., Hoodless, L. J., Melrose, L. A., Marwick, J. A., Tucker, C. S., Haslett, C., Duffin, R., Rossi, A. G. Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway. FASEB J. 27, 1084–1094 (2013). www.fasebj.org</abstract><cop>Bethesda, MD, USA</cop><pub>Federation of American Societies for Experimental Biology</pub><pmid>23195034</pmid><doi>10.1096/fj.12-218990</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-6638 |
| ispartof | The FASEB journal, 2013-03, Vol.27 (3), p.1084-1094 |
| issn | 0892-6638 1530-6860 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3574292 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Amino Acid Chloromethyl Ketones - pharmacology Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Caspase 3 - metabolism Caspase 9 - metabolism Caspase Inhibitors - pharmacology Cell Survival - drug effects Danio rerio Dose-Response Relationship, Drug Down-Regulation - drug effects Female Flavones - pharmacology Humans inflammation Male Myeloid Cell Leukemia Sequence 1 Protein polyphenols Proteasome Endopeptidase Complex - metabolism Proto-Oncogene Proteins c-bcl-2 - biosynthesis Quinolines - pharmacology Research Communications resolution Zebrafish |
| title | Flavones induce neutrophil apoptosis by down‐regulation of Mcl‐1 via a proteasomal‐dependent pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T20%3A18%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Flavones%20induce%20neutrophil%20apoptosis%20by%20down%E2%80%90regulation%20of%20Mcl%E2%80%901%20via%20a%20proteasomal%E2%80%90dependent%20pathway&rft.jtitle=The%20FASEB%20journal&rft.au=Lucas,%20Christopher%20D.&rft.date=2013-03&rft.volume=27&rft.issue=3&rft.spage=1084&rft.epage=1094&rft.pages=1084-1094&rft.issn=0892-6638&rft.eissn=1530-6860&rft_id=info:doi/10.1096/fj.12-218990&rft_dat=%3Cproquest_pubme%3E1551632592%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1551632592&rft_id=info:pmid/23195034&rfr_iscdi=true |